Correlation of clinicopathological and microbiological studies in experimental fowl typhoid and pullorum disease in chicken

Fowl typhoid (FT) and pullorum disease (PD) were induced experimentally in 1 week-old White Leghorn chicks by intracrop inoculation of 0.5 ml of 18 hr broth culture of S. Gallinarium (@ 2.4 × 10⁸ organisms ml ^-1) and S. Pullorum (@2.64 × 10⁸ organisms ml ^-1) in 2 groups of 70 chicks each. Third group of 45 chicks inoculated with 0.5 ml of sterile broth served as control. Viable bacterial counts were determined in liver and spleen and correlated with clinicopathological changes. It was observed that anaemia (a characteristic feature in FT) was correlated negatively and various pathological changes positively with viable counts in FT.