Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis

Charles R. Sims; Siraya Jaijakul; John Mohr; Jose Rodriguez; Malcolm Finkelman; Luis Ostrosky-Zeichner

doi:10.1128/JCM.00773-12

Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis

Charles R. Sims, Siraya Jaijakul, John Mohr, Jose Rodriguez, Malcolm Finkelman, Luis Ostrosky-Zeichner

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The correlation of β-glucan (BG) levels with clinical outcomes in invasive candidiasis (IC) remains unknown. Patients with proven IC were followed prospectively from diagnosis to outcome with twice-weekly serum BG sampling. Correlation of BG with clinical outcome was assessed in each patient. BG levels tend to decrease in successfully treated patients and increase in treatment failures. BG levels may be useful as surrogates for outcome evaluation of IC.

Original language	English (US)
Pages (from-to)	2104-2106
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	50
Issue number	6
DOIs	https://doi.org/10.1128/JCM.00773-12
State	Published - Jun 2012

ASJC Scopus subject areas

Microbiology (medical)

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title = "Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis",

abstract = "The correlation of β-glucan (BG) levels with clinical outcomes in invasive candidiasis (IC) remains unknown. Patients with proven IC were followed prospectively from diagnosis to outcome with twice-weekly serum BG sampling. Correlation of BG with clinical outcome was assessed in each patient. BG levels tend to decrease in successfully treated patients and increase in treatment failures. BG levels may be useful as surrogates for outcome evaluation of IC.",

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AU - Sims, Charles R.

AU - Jaijakul, Siraya

AU - Mohr, John

AU - Rodriguez, Jose

AU - Finkelman, Malcolm

AU - Ostrosky-Zeichner, Luis

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N2 - The correlation of β-glucan (BG) levels with clinical outcomes in invasive candidiasis (IC) remains unknown. Patients with proven IC were followed prospectively from diagnosis to outcome with twice-weekly serum BG sampling. Correlation of BG with clinical outcome was assessed in each patient. BG levels tend to decrease in successfully treated patients and increase in treatment failures. BG levels may be useful as surrogates for outcome evaluation of IC.

AB - The correlation of β-glucan (BG) levels with clinical outcomes in invasive candidiasis (IC) remains unknown. Patients with proven IC were followed prospectively from diagnosis to outcome with twice-weekly serum BG sampling. Correlation of BG with clinical outcome was assessed in each patient. BG levels tend to decrease in successfully treated patients and increase in treatment failures. BG levels may be useful as surrogates for outcome evaluation of IC.

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Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis

Abstract

ASJC Scopus subject areas

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