TY - JOUR
T1 - Correlation between bone turnover markers and bone mineral density in patients undergoing long-term anti-osteoporosis treatment
T2 - A systematic review and meta-analysis
AU - Hong, Lingyun
AU - Liu, Dan
AU - Wu, Feng
AU - Wang, Meiqi
AU - Cen, Yu
AU - Ma, Lan
N1 - Funding Information:
This research was funded by the Special Foundation for the Development of Strategic Emerging Industries of Shenzhen, grant number JSGG20160428181846047, and Science and Technology Planning Project of Shenzhen Municipality, grant number GJHS20170314165540863. We thank Tsinghua University for its generous support of necessary software and access to databases. We are thankful to Chaowen Xue, Shihe Wu, and Jieying Li for their assistance with the writing of this article.
Publisher Copyright:
© 2020 by the authors.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - This systematic review and meta-analysis aimed to evaluate the correlations between the bone turnover markers (BTMs) and the bone mineral density (BMD) in patients treated for primary osteoporosis and to identify promising BTMs for the prediction of future BMD changes. The PubMed, EMBASE, Cochrane Library, andWeb of Science databases were searched for relevant studies that investigated the relationship between the BTMs and the BMD changes in patients treated for osteoporosis. All significant correlation coefficients of the baseline BTMs or changes in BTMs from baseline with the BMD changes from baseline under different interventions from eligible studies were used for systematic review and the subgroup analyses. The correlations were analyzed in terms of bone sites, intervention, time duration of BTMs measurements, and time duration of BMD measurements. Twenty-two records reporting correlation coefficients and the corresponding p-values were included, 13 of which were enrolled in the further subgroup analyses. The combined results from the systematic review and meta-analyses indicated that the changes in osteocalcin (OC), procollagen type I N propeptide (PINP), and urine N-terminal crosslinking telopeptide of type I collagen (U-NTX), or the PINP at baseline tended to be useful in evaluating the long-term BMD changes after drug intervention.
AB - This systematic review and meta-analysis aimed to evaluate the correlations between the bone turnover markers (BTMs) and the bone mineral density (BMD) in patients treated for primary osteoporosis and to identify promising BTMs for the prediction of future BMD changes. The PubMed, EMBASE, Cochrane Library, andWeb of Science databases were searched for relevant studies that investigated the relationship between the BTMs and the BMD changes in patients treated for osteoporosis. All significant correlation coefficients of the baseline BTMs or changes in BTMs from baseline with the BMD changes from baseline under different interventions from eligible studies were used for systematic review and the subgroup analyses. The correlations were analyzed in terms of bone sites, intervention, time duration of BTMs measurements, and time duration of BMD measurements. Twenty-two records reporting correlation coefficients and the corresponding p-values were included, 13 of which were enrolled in the further subgroup analyses. The combined results from the systematic review and meta-analyses indicated that the changes in osteocalcin (OC), procollagen type I N propeptide (PINP), and urine N-terminal crosslinking telopeptide of type I collagen (U-NTX), or the PINP at baseline tended to be useful in evaluating the long-term BMD changes after drug intervention.
KW - Bone mineral density
KW - Bone turnover markers
KW - Correlation
KW - Osteoporosis
KW - Systematic review and meta-analysis
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U2 - 10.3390/app10030832
DO - 10.3390/app10030832
M3 - Article
AN - SCOPUS:85081534229
SN - 2076-3417
VL - 10
JO - Applied Sciences (Switzerland)
JF - Applied Sciences (Switzerland)
IS - 3
M1 - 832
ER -