TY - JOUR
T1 - Coronary Artery Disease and Aspirin Intolerance
T2 - Background and Insights on Current Management
AU - Thakker, Ravi A.
AU - Salazar, Leonardo
AU - Jazar, Deaa Abu
AU - Bhakta, Pooja
AU - Baker, Bryan
AU - Patel, Chandani
AU - Elbadawi, Ayman
AU - Agarwal, Mayank
AU - Albaeni, Aiham
AU - Saleh, Mohammed
AU - Esclovan, Jonathan
AU - El Haddad, Danielle
AU - Alwash, Hashim
AU - Kalra, Ankur
AU - Goel, Sachin S.
AU - Widmer, Robert Jay
AU - Chatila, Khaled
AU - Khalife, Wissam
AU - Motiwala, Afaq
AU - McCracken, Jennifer
AU - Jneid, Hani
AU - Gilani, Syed
N1 - Funding Information:
The authors did not receive funding for this manuscript. No Rapid Service Fee was received by the journal for the publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Study conception and design: R.A.T., L.S. Manuscript preparation/drafting: R.A.T., L.S, D.A.J., P.B., B.B, C.P., M.A., J.E., D.E.H., H.A. Expert review and critical evaluation of manuscript: A.E., A.A., M.S., A.K., S.S.G., R.J.W., K.C., W.K., A.M., J.M., H.J., S.G. Ravi A. Thakker, MD at the time of this manuscript preparation and submission serves on the editorial board of Cardiology and Therapy. Ankur Kalra, MD and Ayman Elbadawi, MD at the time of this manuscript preparation and submission serve on the advisory board of Cardiology and Therapy. Leonardo Salazar, MD, Deaa Abu Jazar, MD, Pooja Bhakta, DO, Bryan Baker, DO, Chandani Patel, DO, Mayank Agarwal, MD, Aiham Albaeni, MD, Mohammed Saleh, MD, Jonathan Esclovan, MD, Danielle El Haddad, MD, Hashim Alwash, MD, Ankur Kalra, MD, Sachin Goel, MD, Robert Jay Widmer, MD, Khaled Chatila, MD, Wissam Khalife, MD, Afaq Motiwala, MD, Jennifer McCracken, MD, Hani Jneid, MD, Syed Gilani, MD have nothing to disclose pertinent to this manuscript. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/6
Y1 - 2022/6
N2 - Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.
AB - Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.
KW - Acute coronary syndrome
KW - Aspirin intolerance
KW - Coronary artery disease
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U2 - 10.1007/s40119-022-00255-9
DO - 10.1007/s40119-022-00255-9
M3 - Review article
AN - SCOPUS:85127230314
VL - 11
SP - 175
EP - 183
JO - Cardiology and Therapy
JF - Cardiology and Therapy
SN - 2193-8261
IS - 2
ER -