TY - CHAP
T1 - Coregulators in toxicology
AU - Rüegg, Joëlle
AU - Hedengran-Faulds, Malin
AU - Hase, Manuela
AU - Pongratz, Ingemar
AU - Gustafsson, Jan Åke
N1 - Publisher Copyright:
© 2008 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The response to a xenobiotic insult is mainly mediated by the bHLHPAS protein aryl hydrocarbon receptor (AhR) and the nuclear receptors SXR/PXR and CAR. They are therefore called xenosensors. The binding of toxic substances to these receptors results in the transcription of genes encoding enzymes involved in the metabolism and transport of xenobiotics and their metabolites. Coregulators play an important role in the signal transduction of AhR, SXR/PXR, and CAR. Many of these coregulators are also crucial for the signaling of the hormone receptors in the nuclear receptor family. Thus, in the presence of xenobiotics, the recruitment of coactivators to the xenosensors can lead to impaired hormonal signaling. This is one of the mechanisms that may explain endocrine disruption (impaired hormone response after chemical exposure), a phenomenon that has raised attention and concern during recent decades.
AB - The response to a xenobiotic insult is mainly mediated by the bHLHPAS protein aryl hydrocarbon receptor (AhR) and the nuclear receptors SXR/PXR and CAR. They are therefore called xenosensors. The binding of toxic substances to these receptors results in the transcription of genes encoding enzymes involved in the metabolism and transport of xenobiotics and their metabolites. Coregulators play an important role in the signal transduction of AhR, SXR/PXR, and CAR. Many of these coregulators are also crucial for the signaling of the hormone receptors in the nuclear receptor family. Thus, in the presence of xenobiotics, the recruitment of coactivators to the xenosensors can lead to impaired hormonal signaling. This is one of the mechanisms that may explain endocrine disruption (impaired hormone response after chemical exposure), a phenomenon that has raised attention and concern during recent decades.
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U2 - 10.1142/9789812819178_0017
DO - 10.1142/9789812819178_0017
M3 - Chapter
AN - SCOPUS:84969601873
SN - 9812705368
SN - 9789812705365
SP - 530
EP - 551
BT - NR Coregulators and Human Diseases
PB - World Scientific Publishing Co.
ER -