Copper catalyzed conjugate addition of highly functionalized arylmagnesium compounds to enones

Greta Varchi; Alfredo Ricci; Gérard Cahiez; Paul Knochel

doi:10.1016/S0040-4020(00)00127-7

Copper catalyzed conjugate addition of highly functionalized arylmagnesium compounds to enones

Greta Varchi, Alfredo Ricci, Gérard Cahiez, Paul Knochel

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Highly functionalized arylmagnesium bromides are readily prepared by an iodine-magnesium exchange reaction. In the presence of catalytic amounts of copper(I) salts and chlorotrimethylsilane, they add to various enones leading to the conjugate addition products in 66-89% yield. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	2727-2731
Number of pages	5
Journal	Tetrahedron
Volume	56
Issue number	18
DOIs	https://doi.org/10.1016/S0040-4020(00)00127-7
State	Published - Apr 28 2000

Keywords

Conjugate addition
Copper catalysis
Polyfunctional organomagnesium compounds

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(00)00127-7

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title = "Copper catalyzed conjugate addition of highly functionalized arylmagnesium compounds to enones",

abstract = "Highly functionalized arylmagnesium bromides are readily prepared by an iodine-magnesium exchange reaction. In the presence of catalytic amounts of copper(I) salts and chlorotrimethylsilane, they add to various enones leading to the conjugate addition products in 66-89% yield. (C) 2000 Elsevier Science Ltd.",

keywords = "Conjugate addition, Copper catalysis, Polyfunctional organomagnesium compounds",

author = "Greta Varchi and Alfredo Ricci and G{\'e}rard Cahiez and Paul Knochel",

note = "Funding Information: We thank the DFG (Leibniz program) and the Fonds der Chemischen Industrie for generous support. We thank Degussa AG (Hanau), Chemetall GmbH (Frankfurt), BASF AG (Ludwigshafen) and Witco AG (Bergkamen) for generous gift of chemicals. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.",

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doi = "10.1016/S0040-4020(00)00127-7",

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T1 - Copper catalyzed conjugate addition of highly functionalized arylmagnesium compounds to enones

AU - Varchi, Greta

AU - Ricci, Alfredo

AU - Cahiez, Gérard

AU - Knochel, Paul

N1 - Funding Information: We thank the DFG (Leibniz program) and the Fonds der Chemischen Industrie for generous support. We thank Degussa AG (Hanau), Chemetall GmbH (Frankfurt), BASF AG (Ludwigshafen) and Witco AG (Bergkamen) for generous gift of chemicals. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.

PY - 2000/4/28

Y1 - 2000/4/28

N2 - Highly functionalized arylmagnesium bromides are readily prepared by an iodine-magnesium exchange reaction. In the presence of catalytic amounts of copper(I) salts and chlorotrimethylsilane, they add to various enones leading to the conjugate addition products in 66-89% yield. (C) 2000 Elsevier Science Ltd.

AB - Highly functionalized arylmagnesium bromides are readily prepared by an iodine-magnesium exchange reaction. In the presence of catalytic amounts of copper(I) salts and chlorotrimethylsilane, they add to various enones leading to the conjugate addition products in 66-89% yield. (C) 2000 Elsevier Science Ltd.

KW - Conjugate addition

KW - Copper catalysis

KW - Polyfunctional organomagnesium compounds

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JO - Tetrahedron

JF - Tetrahedron

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ER -

Copper catalyzed conjugate addition of highly functionalized arylmagnesium compounds to enones

Abstract

Keywords

ASJC Scopus subject areas

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