Copper catalyzed conjugate addition of highly functionalized arylmagnesium compounds to enones

Greta Varchi, Alfredo Ricci, Gérard Cahiez, Paul Knochel

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Highly functionalized arylmagnesium bromides are readily prepared by an iodine-magnesium exchange reaction. In the presence of catalytic amounts of copper(I) salts and chlorotrimethylsilane, they add to various enones leading to the conjugate addition products in 66-89% yield. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2727-2731
Number of pages5
JournalTetrahedron
Volume56
Issue number18
DOIs
StatePublished - Apr 28 2000

Keywords

  • Conjugate addition
  • Copper catalysis
  • Polyfunctional organomagnesium compounds

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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