Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

Takuro Nakamura, David A. Largaespada, John D. Shaughnessy, Nancy A. Jenkins, Neal G. Copeland

Research output: Contribution to journalArticlepeer-review

272 Scopus citations

Abstract

Retroviruses induce myeloid leukaemia in BXH-2 mice by the insertional mutation of cellular proto-oncogenes or tumour suppressor genes. Disease genes can thus be identified by proviral tagging through the identification of common viral integration sites in BXH-2 leukaemia. Here, we describe a new approach for proviral tagging that greatly facilitates the identification of BXH-2 leukaemia genes. Using this approach, we identify three genes whose expression is activated by proviral integration in BXH-2 leukaemias; Hoxa7, Hoxa9, and a Pbx1-related homeobox gene, Meis1. Proviral activation of Hoxa7 or Hoxa9 is strongly correlated with proviral activation of Meis1 implying that Hoxa7 and Hoxa9 cooperate with Meis1 in leukaemia formation. These studies provide the first genetic evidence that Pbx1-related genes cooperate with Hox genes in leukaemia formation and identify a number of new murine myeloid leukaemia genes.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalNature Genetics
Volume12
Issue number2
DOIs
StatePublished - Feb 1 1996

ASJC Scopus subject areas

  • Genetics

Fingerprint

Dive into the research topics of 'Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias'. Together they form a unique fingerprint.

Cite this