To investigate the efficacy of conversion from calcineurin-inhibitor (CNI) to rapamycin in liver recipients with CNI-associated renal insufficiency. This retrospective study examined the liver transplant recipients who had switched from CNI to rapamycin between January 2004 and June 2008 in the first affiliated hospital of Sun Yat-sen University. The data of renal function before and after the conversion were analyzed by Wilcoxon sum rank test, and rapamycin-related adverse effects were also observed. Compared with that before conversion, the renal funtion 4 months after the conversion improved significantly (P<0.05). The blood lipid level 3 months after the conversion increased significantly (P<0.05) but were well controlled. Rapamycin can be used safely as a good alternative in liver transplant recipients with CNI-related renal insufficiency.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nan fang yi ke da xue xue bao = Journal of Southern Medical University|
|State||Published - Nov 2009|
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