Convergence of lipid homeostasis through liver X and thyroid hormone receptors

Anders Berkenstam, Mathias Färnegårdh, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Members of the nuclear receptor gene family act as biological rheostats to maintain metabolic homeostasis in response to endocrine and nutritional changes. The liver X (LXR) and thyroid hormone (TR) receptors have been shown to regulate overlapping but distinct metabolic pathways important for overall lipid homeostasis. Dyslipidemia is one out of four key determinants for cardiovascular risk and both LXRs and TRs may provide attractive targets for intervention of cardiovascular disease. In this review we will compare the two receptor systems to highlight similarities and differences in structure and function with implications for development of novel treatments for dyslipidemia and atherosclerosis.

Original languageEnglish (US)
Pages (from-to)707-717
Number of pages11
JournalMechanisms of Ageing and Development
Volume125
Issue number10-11 SPEC. ISS.
DOIs
StatePublished - Jan 1 2004

Keywords

  • Atherosclerosis
  • Dyslipidemia
  • Liver X receptor
  • Nuclear receptor
  • Thyroid hormone receptor

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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