Convection-Enhanced Delivery and Principles of Extracellular Transport in the Brain

Amir H. Faraji, Sibi Rajendran, Andrea S. Jaquins-Gerstl, Hunter J. Hayes, R. Mark Richardson

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Stereotactic neurosurgery involves a targeted intervention based on congruence of image guidance to a reference fiducial system. This discipline has widespread applications in radiosurgery, tumor therapy, drug delivery, functional lesioning, and neuromodulation. In this article, we focused on convection-enhanced delivery to deliver therapeutic agents to the brain addressing areas of research and clinical development. We performed a robust literature review of all relevant articles highlighting current efforts and challenges of making this delivery technique more widely understood. We further described key biophysical properties of molecular transport in the extracellular space that may impact the efficacy and control of drug delivery using stereotactic methods. Understanding these principles is critical for further refinement of predictive models that can inform advances in stereotactic techniques for convection-enhanced delivery of therapeutic agents to the brain.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalWorld neurosurgery
Volume151
DOIs
StatePublished - Jul 2021

Keywords

  • Brain transport
  • Convection-enhanced delivery
  • Drug delivery
  • Electro-osmosis
  • Electrokinetic transport
  • Tortuosity

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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