Controlled release of encapsulated cargo from a DNA icosahedron using a chemical trigger

Anusuya Banerjee; Dhiraj Bhatia; Anand Saminathan; Saikat Chakraborty; Shaunak Kar; Yamuna Krishnan

doi:10.1002/anie.201302759

Controlled release of encapsulated cargo from a DNA icosahedron using a chemical trigger

Anusuya Banerjee, Dhiraj Bhatia, Anand Saminathan, Saikat Chakraborty, Shaunak Kar, Yamuna Krishnan

Houston Methodist

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

DNA Trojan horse: A DNA icosahedron (black, see scheme) held together with aptamers (red) was used to encapsulate molecular cargo such as fluorescent dextran (green). In the presence of a molecular trigger (gray hexagons), the aptamers fold back leading to opening of the icosahedron and simultaneous release of the encapsulated cargo.

Original language	English (US)
Pages (from-to)	6854-6857
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	27
DOIs	https://doi.org/10.1002/anie.201302759
State	Published - Jul 1 2013

Keywords

DNA icosahedron
aptamers
cargo release
drug delivery
encapsulation

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201302759

Cite this

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abstract = "DNA Trojan horse: A DNA icosahedron (black, see scheme) held together with aptamers (red) was used to encapsulate molecular cargo such as fluorescent dextran (green). In the presence of a molecular trigger (gray hexagons), the aptamers fold back leading to opening of the icosahedron and simultaneous release of the encapsulated cargo.",

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AU - Chakraborty, Saikat

AU - Kar, Shaunak

AU - Krishnan, Yamuna

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KW - aptamers

KW - cargo release

KW - drug delivery

KW - encapsulation

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Controlled release of encapsulated cargo from a DNA icosahedron using a chemical trigger

Abstract

Keywords

ASJC Scopus subject areas

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