Controlled-release microchips

Sadhana Sharma, A. Jasper Nijdam, Piyush M. Sinha, Robbie J. Walczak, Xuewu Liu, Mark M.C. Cheng, Mauro Ferrari

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Efficient drug delivery remains an important challenge in medicine: continuous release of therapeutic agents over extended time periods in accordance with a predetermined temporal profile; local delivery at a constant rate to the tumour microenvironment to overcome much of the systemic toxicity and to improve antitumour efficacy; improved ease of administration, and increasing patient compliance required are some of the unmet needs of the present drug delivery technology. Microfabrication technology has enabled the development of novel controlled-release microchips with capabilities not present in the current treatment modalities. In this review, the current status and future prospects of different types of controlled-release microchips are summarised and analysed with reference to microneedle-based microchips, as well as providing an in-depth focus on microreservoir-based and nanoporous microchips.

Original languageEnglish (US)
Pages (from-to)379-394
Number of pages16
JournalExpert Opinion on Drug Delivery
Volume3
Issue number3
DOIs
StatePublished - May 2006

Keywords

  • Controlled release
  • MicroCHIPS
  • Microelectromechanical systems
  • Microneedles
  • Microreservoirs
  • Nanoporous silicon microchips

ASJC Scopus subject areas

  • Pharmaceutical Science

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