The open-loop gain G0 reference pressure P0 and basal heartrate R0 of the blood-pressure regulatory system have been estimated under four different experimental conditions by employing an aortic balloon and assuming a theoretical approach based on a 1st-order linear model. Mean values of 1·7-3·7, 75-130 mmHg, and 95-130 beats/min were obtained for G0, P0 and R0, respectively. Significant variations in these parameters were observed when the anaesthetic conditions were changed. It is suggested that G0, P0 and R0 may have useful clinical applications both in characterising hypotensive and hypertensive syndromes and also in assessing the effect of anaesthetic agents.
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