Control of virus-induced lymphoproliferation: Epstein-Barr virus- induced lymphoproliferation and host immunity

C. M. Rooney, C. A. Smith, H. E. Heslop

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Epstein-Barr virus (EBV) is a latent herpesvirus that is associated with a number of tumors. EBV-infected cells show three patterns of latency ranging from type 1, where only one EBV-encoded antigen is expressed, to type 3, where all nine latent cycle proteins encoded by EBV are expressed. Malignancies exhibiting the type 3 latency pettern are highly immunogenic and occur only in immunocompromised patients. It has recently been shown that adoptive immunotherepy with EBV-specific cytotoxic T lymphocytes is an effective therapy for such tumors. Immunotherapy strategies and approaches to increase tumor immunogenicity are now being evaluated in tumors expressing type 2 latency.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalMolecular Medicine Today
Volume3
Issue number1
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics

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