TY - JOUR
T1 - Control of primary osteosarcoma with chemotherapy
AU - Jaffe, Norman
AU - Robertson, Resa
AU - Takaue, Yoichi
AU - Cangir, Ayten
AU - Wallace, Sidney
AU - Carrasco, Humberto
AU - Eftekhari, Farzin
AU - Ayala, Alberto
AU - Wang, Alexander
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1985/8/1
Y1 - 1985/8/1
N2 - High‐dose methotrexate with citrovorum factor “rescue” (MTX‐CF) produced an apparent complete response of the primary tumor in three patients with osteosarcoma. The response was sustained with MTX‐CF, intra‐arterial cis‐diamminedichloroplatinum II (CDP) and Adriamycin (doxorubicin) for 18 months. Treatment was then electively discontinued. Local recurrence occurred in two patients, 6 and 4 months later, respectively. MTX‐CF was reinstated and a complete response was again achieved in one patient. This has been maintained for 15+ months with MTX‐CF and intra‐arterial CDP administered for 13 of the 15+ months. Reinduction with MTX‐CF failed in the second relapsed patient but an apparent remission was again achieved with radiation and intra‐arterial CDP. This has been maintained with intravenous CDP, cyclophosphamide and phenylalanine mustard for 14+ months. A complete response in the primary tumor was still present in the nonrelapsed patient, 42 months from diagnosis. All patients have remained free of pulmonary metastases, 40+ to 42+ months from diagnosis.
AB - High‐dose methotrexate with citrovorum factor “rescue” (MTX‐CF) produced an apparent complete response of the primary tumor in three patients with osteosarcoma. The response was sustained with MTX‐CF, intra‐arterial cis‐diamminedichloroplatinum II (CDP) and Adriamycin (doxorubicin) for 18 months. Treatment was then electively discontinued. Local recurrence occurred in two patients, 6 and 4 months later, respectively. MTX‐CF was reinstated and a complete response was again achieved in one patient. This has been maintained for 15+ months with MTX‐CF and intra‐arterial CDP administered for 13 of the 15+ months. Reinduction with MTX‐CF failed in the second relapsed patient but an apparent remission was again achieved with radiation and intra‐arterial CDP. This has been maintained with intravenous CDP, cyclophosphamide and phenylalanine mustard for 14+ months. A complete response in the primary tumor was still present in the nonrelapsed patient, 42 months from diagnosis. All patients have remained free of pulmonary metastases, 40+ to 42+ months from diagnosis.
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U2 - 10.1002/1097-0142(19850801)56:3<461::AID-CNCR2820560308>3.0.CO;2-L
DO - 10.1002/1097-0142(19850801)56:3<461::AID-CNCR2820560308>3.0.CO;2-L
M3 - Article
C2 - 3873985
AN - SCOPUS:0021809849
VL - 56
SP - 461
EP - 466
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 3
ER -