Control of primary osteosarcoma with chemotherapy

Norman Jaffe, Resa Robertson, Yoichi Takaue, Ayten Cangir, Sidney Wallace, Humberto Carrasco, Farzin Eftekhari, Alberto Ayala, Alexander Wang

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


High‐dose methotrexate with citrovorum factor “rescue” (MTX‐CF) produced an apparent complete response of the primary tumor in three patients with osteosarcoma. The response was sustained with MTX‐CF, intra‐arterial cis‐diamminedichloroplatinum II (CDP) and Adriamycin (doxorubicin) for 18 months. Treatment was then electively discontinued. Local recurrence occurred in two patients, 6 and 4 months later, respectively. MTX‐CF was reinstated and a complete response was again achieved in one patient. This has been maintained for 15+ months with MTX‐CF and intra‐arterial CDP administered for 13 of the 15+ months. Reinduction with MTX‐CF failed in the second relapsed patient but an apparent remission was again achieved with radiation and intra‐arterial CDP. This has been maintained with intravenous CDP, cyclophosphamide and phenylalanine mustard for 14+ months. A complete response in the primary tumor was still present in the nonrelapsed patient, 42 months from diagnosis. All patients have remained free of pulmonary metastases, 40+ to 42+ months from diagnosis.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
Issue number3
StatePublished - Aug 1 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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