Control of gene expression by novel metabolic intermediates

Jan Ake Gustafsson

doi:10.1016/j.jsbmb.2015.04.008

Control of gene expression by novel metabolic intermediates

Jan Ake Gustafsson

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

In view of the recent discoveries of novel nuclear receptors (NRs) whose ligands remain to be determined, metabolic intermediates may be considered as ligands for these receptors and undiscovered or overlooked intermediates may play important roles in regulating gene expression by activating or repressing the action of these nuclear receptors. This article is part of a Special Issue entitled 'Steroid Perspectives'.

Original language	English (US)
Article number	4399
Pages (from-to)	102-104
Number of pages	3
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	153
DOIs	https://doi.org/10.1016/j.jsbmb.2015.04.008
State	Published - Sep 1 2015

Keywords

Bile acid
Ligand
Nuclear receptor
Oxysterol
Steroid

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

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10.1016/j.jsbmb.2015.04.008

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title = "Control of gene expression by novel metabolic intermediates",

abstract = "In view of the recent discoveries of novel nuclear receptors (NRs) whose ligands remain to be determined, metabolic intermediates may be considered as ligands for these receptors and undiscovered or overlooked intermediates may play important roles in regulating gene expression by activating or repressing the action of these nuclear receptors. This article is part of a Special Issue entitled 'Steroid Perspectives'.",

keywords = "Bile acid, Ligand, Nuclear receptor, Oxysterol, Steroid",

author = "Gustafsson, {Jan Ake}",

note = "Funding Information: This paper was supported by the Swedish Research Council, the Texas Emerging Technology Fund under Agreement 18 no. 300-9-1958 and the Robert A. Welch Foundation (E-0004). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.jsbmb.2015.04.008",

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AU - Gustafsson, Jan Ake

N1 - Funding Information: This paper was supported by the Swedish Research Council, the Texas Emerging Technology Fund under Agreement 18 no. 300-9-1958 and the Robert A. Welch Foundation (E-0004). Publisher Copyright: © 2015 Elsevier Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - In view of the recent discoveries of novel nuclear receptors (NRs) whose ligands remain to be determined, metabolic intermediates may be considered as ligands for these receptors and undiscovered or overlooked intermediates may play important roles in regulating gene expression by activating or repressing the action of these nuclear receptors. This article is part of a Special Issue entitled 'Steroid Perspectives'.

AB - In view of the recent discoveries of novel nuclear receptors (NRs) whose ligands remain to be determined, metabolic intermediates may be considered as ligands for these receptors and undiscovered or overlooked intermediates may play important roles in regulating gene expression by activating or repressing the action of these nuclear receptors. This article is part of a Special Issue entitled 'Steroid Perspectives'.

KW - Bile acid

KW - Ligand

KW - Nuclear receptor

KW - Oxysterol

KW - Steroid

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U2 - 10.1016/j.jsbmb.2015.04.008

DO - 10.1016/j.jsbmb.2015.04.008

M3 - Review article

C2 - 25869558

AN - SCOPUS:84941260171

VL - 153

SP - 102

EP - 104

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

SN - 0960-0760

M1 - 4399

ER -

Control of gene expression by novel metabolic intermediates

Abstract

Keywords

ASJC Scopus subject areas

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