Apport des modèles mathématiques et des études biomécaniques dans la prédiction du risque de rupture des anévrysmes de l'aorte abdominale

Translated title of the contribution: Contribution of mathematical models and biomechanical properties in predicting the risk of abdominal aortic aneurysm rupture

Y. Georg, C. Delay, A. Schwein, A. Lejay, F. Thaveau, S. Gaertner, D. Stephan, F. Heim, N. Chakfe

Research output: Contribution to journalShort survey

Abstract

Introduction: Rupture is the worst outcome of abdominal aortic aneurysm (AAA). The decision to operate should include counterbalancing the risk of aneurysm rupture against the risk of aneurysm repair, within the context of a patient's overall life expectancy. Current surgical guidelines are based on population studies, and important variables are missed in predicting individual risk of rupture. Methods: In this literature review, we focused on the contribution of biomechanical and mathematical models in predicting risk of AAA rupture. Results: Anatomical features as diameter asymmetry and lack of tortuosity are shown to be anatomical risk factors of rupture. Wall stiffness (due to modifications of elastin and collagen composition) and increased inflammatory response are also factors that affect the structural integrity of the AAA wall. Biomechanical studies showed that wall strength is lower in ruptured than non-ruptured AAA. Intra-luminal thrombus also has a big role to play in the occurrence of rupture. Current mathematical models allow more variables to be included in predicting individual risk of rupture. Conclusion: Moving away from using maximal transverse diameter of the AAA as a unique predictive factor and instead including biological, structural and biomechanical variables in predicting individual risk of rupture will be essential in the future and will help gain precision and accuracy in surgical indications.

Translated title of the contributionContribution of mathematical models and biomechanical properties in predicting the risk of abdominal aortic aneurysm rupture
Original languageFrench
Pages (from-to)63-68
Number of pages6
JournalJournal des Maladies Vasculaires
Volume41
Issue number1
DOIs
StatePublished - Feb 1 2016

Keywords

  • Abdominal aortic aneurysm
  • Biomechanical studies
  • Mathematical models
  • Risk of rupture

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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