Contribution of genes to the changes on body composition components: A two-year longitudinal study in a small cohort of twins

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Adam Domonkos Tarnoki, D. L. Tarnoki, A. A. Molnar, V. Berczi, Zsolt Garami, K. Karlinger

Context. High heritability of body composition variables is well-known, however, longitudinal effect of genes is still unclear. Objective. The aim of this study was to investigate the pattern of longitudinal changes in anthropometric variables in a small cohort of twins. Design. Longitudinal classical twin study, performed in 2009 and in 2011 on the same twin pairs. Subjects and Methods. Eighteen healthy adult Hungarian twin pairs (13 monozygotic [MZ], 5 dizygotic [DZ]; mean age 54.0 ± 15.2 years; average body mass index 24.4±5.4 kg/m2 in 2009 and 25.1±4.7 kg/m2 in 2011, respectively) recruited from the Hungarian Twin Registry underwent bioimpedance analysis (OMRON). Results. Significant, higher positive intrapair correlations were detected in the longitudinal change in weight (p<0.05), body fat mass (p<0.01), non-fat mass (p<0.01), and body mass index (p<0.01) in MZ compared to DZ twins, suggesting the possibility of longitudinal genetic determinants. Negative associations were observed with regard to the two-year change in waist and hip circumferences, suggesting the longitudinal role of environmental factors in these phenotypes. Conclusions. The findings of the present human twin study suggest that weight, body fat mass, non-fat mass, and body mass index are determined genetically and longer exposure to pathologic environmental factors is necessary to elicit alterations in the regulation of these parameters. Longer-term confirmation in a larger sample is required to confirm these results.

Original languageEnglish
Pages (from-to)489-498
Number of pages10
JournalActa Endocrinologica
Volume9
Issue number3
DOIs
StatePublished - Jul 1 2013

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Contribution of genes to the changes on body composition components : A two-year longitudinal study in a small cohort of twins. / Tarnoki, Adam Domonkos; Tarnoki, D. L.; Molnar, A. A.; Berczi, V.; Garami, Zsolt; Karlinger, K.

In: Acta Endocrinologica, Vol. 9, No. 3, 01.07.2013, p. 489-498.

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Harvard

Tarnoki, AD, Tarnoki, DL, Molnar, AA, Berczi, V, Garami, Z & Karlinger, K 2013, 'Contribution of genes to the changes on body composition components: A two-year longitudinal study in a small cohort of twins' Acta Endocrinologica, vol. 9, no. 3, pp. 489-498. https://doi.org/10.4183/aeb.2013.489

APA

Tarnoki, A. D., Tarnoki, D. L., Molnar, A. A., Berczi, V., Garami, Z., & Karlinger, K. (2013). Contribution of genes to the changes on body composition components: A two-year longitudinal study in a small cohort of twins. Acta Endocrinologica, 9(3), 489-498. https://doi.org/10.4183/aeb.2013.489

Vancouver

Tarnoki AD, Tarnoki DL, Molnar AA, Berczi V, Garami Z, Karlinger K. Contribution of genes to the changes on body composition components: A two-year longitudinal study in a small cohort of twins. Acta Endocrinologica. 2013 Jul 1;9(3):489-498. https://doi.org/10.4183/aeb.2013.489

Author

Tarnoki, Adam Domonkos ; Tarnoki, D. L. ; Molnar, A. A. ; Berczi, V. ; Garami, Zsolt ; Karlinger, K. / Contribution of genes to the changes on body composition components : A two-year longitudinal study in a small cohort of twins. In: Acta Endocrinologica. 2013 ; Vol. 9, No. 3. pp. 489-498.

BibTeX

@article{75053a6f939f4439b00139617b3d03e0,
title = "Contribution of genes to the changes on body composition components: A two-year longitudinal study in a small cohort of twins",
abstract = "Context. High heritability of body composition variables is well-known, however, longitudinal effect of genes is still unclear. Objective. The aim of this study was to investigate the pattern of longitudinal changes in anthropometric variables in a small cohort of twins. Design. Longitudinal classical twin study, performed in 2009 and in 2011 on the same twin pairs. Subjects and Methods. Eighteen healthy adult Hungarian twin pairs (13 monozygotic [MZ], 5 dizygotic [DZ]; mean age 54.0 ± 15.2 years; average body mass index 24.4±5.4 kg/m2 in 2009 and 25.1±4.7 kg/m2 in 2011, respectively) recruited from the Hungarian Twin Registry underwent bioimpedance analysis (OMRON). Results. Significant, higher positive intrapair correlations were detected in the longitudinal change in weight (p<0.05), body fat mass (p<0.01), non-fat mass (p<0.01), and body mass index (p<0.01) in MZ compared to DZ twins, suggesting the possibility of longitudinal genetic determinants. Negative associations were observed with regard to the two-year change in waist and hip circumferences, suggesting the longitudinal role of environmental factors in these phenotypes. Conclusions. The findings of the present human twin study suggest that weight, body fat mass, non-fat mass, and body mass index are determined genetically and longer exposure to pathologic environmental factors is necessary to elicit alterations in the regulation of these parameters. Longer-term confirmation in a larger sample is required to confirm these results.",
keywords = "Body fat mass, Body mass index, Environment, Genetics, Heritability",
author = "Tarnoki, {Adam Domonkos} and Tarnoki, {D. L.} and Molnar, {A. A.} and V. Berczi and Zsolt Garami and K. Karlinger",
year = "2013",
month = "7",
day = "1",
doi = "10.4183/aeb.2013.489",
language = "English",
volume = "9",
pages = "489--498",
journal = "Acta Endocrinologica",
issn = "0001-5598",
publisher = "Munksgaard International Publishers",
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}

RIS

TY - JOUR

T1 - Contribution of genes to the changes on body composition components

T2 - Acta Endocrinologica

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, D. L.

AU - Molnar, A. A.

AU - Berczi, V.

AU - Garami, Zsolt

AU - Karlinger, K.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Context. High heritability of body composition variables is well-known, however, longitudinal effect of genes is still unclear. Objective. The aim of this study was to investigate the pattern of longitudinal changes in anthropometric variables in a small cohort of twins. Design. Longitudinal classical twin study, performed in 2009 and in 2011 on the same twin pairs. Subjects and Methods. Eighteen healthy adult Hungarian twin pairs (13 monozygotic [MZ], 5 dizygotic [DZ]; mean age 54.0 ± 15.2 years; average body mass index 24.4±5.4 kg/m2 in 2009 and 25.1±4.7 kg/m2 in 2011, respectively) recruited from the Hungarian Twin Registry underwent bioimpedance analysis (OMRON). Results. Significant, higher positive intrapair correlations were detected in the longitudinal change in weight (p<0.05), body fat mass (p<0.01), non-fat mass (p<0.01), and body mass index (p<0.01) in MZ compared to DZ twins, suggesting the possibility of longitudinal genetic determinants. Negative associations were observed with regard to the two-year change in waist and hip circumferences, suggesting the longitudinal role of environmental factors in these phenotypes. Conclusions. The findings of the present human twin study suggest that weight, body fat mass, non-fat mass, and body mass index are determined genetically and longer exposure to pathologic environmental factors is necessary to elicit alterations in the regulation of these parameters. Longer-term confirmation in a larger sample is required to confirm these results.

AB - Context. High heritability of body composition variables is well-known, however, longitudinal effect of genes is still unclear. Objective. The aim of this study was to investigate the pattern of longitudinal changes in anthropometric variables in a small cohort of twins. Design. Longitudinal classical twin study, performed in 2009 and in 2011 on the same twin pairs. Subjects and Methods. Eighteen healthy adult Hungarian twin pairs (13 monozygotic [MZ], 5 dizygotic [DZ]; mean age 54.0 ± 15.2 years; average body mass index 24.4±5.4 kg/m2 in 2009 and 25.1±4.7 kg/m2 in 2011, respectively) recruited from the Hungarian Twin Registry underwent bioimpedance analysis (OMRON). Results. Significant, higher positive intrapair correlations were detected in the longitudinal change in weight (p<0.05), body fat mass (p<0.01), non-fat mass (p<0.01), and body mass index (p<0.01) in MZ compared to DZ twins, suggesting the possibility of longitudinal genetic determinants. Negative associations were observed with regard to the two-year change in waist and hip circumferences, suggesting the longitudinal role of environmental factors in these phenotypes. Conclusions. The findings of the present human twin study suggest that weight, body fat mass, non-fat mass, and body mass index are determined genetically and longer exposure to pathologic environmental factors is necessary to elicit alterations in the regulation of these parameters. Longer-term confirmation in a larger sample is required to confirm these results.

KW - Body fat mass

KW - Body mass index

KW - Environment

KW - Genetics

KW - Heritability

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UR - http://www.scopus.com/inward/citedby.url?scp=84883145572&partnerID=8YFLogxK

U2 - 10.4183/aeb.2013.489

DO - 10.4183/aeb.2013.489

M3 - Article

VL - 9

SP - 489

EP - 498

JO - Acta Endocrinologica

JF - Acta Endocrinologica

SN - 0001-5598

IS - 3

ER -

ID: 2701223