Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis

Michael Engelbert; Eleftherios Mylonakis; Frederick M. Ausubel; Stephen B. Calderwood; Michael S. Gilmore

doi:10.1128/IAI.72.6.3628-3633.2004

Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis

Michael Engelbert, Eleftherios Mylonakis, Frederick M. Ausubel, Stephen B. Calderwood, Michael S. Gilmore

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.

Original language	English (US)
Pages (from-to)	3628-3633
Number of pages	6
Journal	Infection and Immunity
Volume	72
Issue number	6
DOIs	https://doi.org/10.1128/IAI.72.6.3628-3633.2004
State	Published - Jun 2004

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.72.6.3628-3633.2004

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abstract = "Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.",

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AU - Engelbert, Michael

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AU - Calderwood, Stephen B.

AU - Gilmore, Michael S.

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AB - Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.

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Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis

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ASJC Scopus subject areas

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