Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis

Michael Engelbert, Eleftherios Mylonakis, Frederick M. Ausubel, Stephen B. Calderwood, Michael S. Gilmore

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.

Original languageEnglish (US)
Pages (from-to)3628-3633
Number of pages6
JournalInfection and Immunity
Volume72
Issue number6
DOIs
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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