TY - JOUR
T1 - Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis
AU - Engelbert, Michael
AU - Mylonakis, Eleftherios
AU - Ausubel, Frederick M.
AU - Calderwood, Stephen B.
AU - Gilmore, Michael S.
PY - 2004/6
Y1 - 2004/6
N2 - Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.
AB - Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.
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U2 - 10.1128/IAI.72.6.3628-3633.2004
DO - 10.1128/IAI.72.6.3628-3633.2004
M3 - Article
C2 - 15155673
AN - SCOPUS:2542570324
SN - 0019-9567
VL - 72
SP - 3628
EP - 3633
JO - Infection and Immunity
JF - Infection and Immunity
IS - 6
ER -