Contribution of 'clinically negligible' residual kidney function to clearance of uremic solutes

Stephanie M. Toth-Manikowski, Tammy L. Sirich, Timothy W. Meyer, Thomas H. Hostetter, Seungyoung Hwang, Natalie S. Plummer, Xin Hai, Josef Coresh, Neil R. Powe, Tariq Shafi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Residual kidney function (RKF) is thought to exert beneficial effects through clearance of uremic toxins. However, the level of native kidney function where clearance becomes negligible is not known. Methods: We aimed to assess whether levels of nonurea solutes differed among patients with 'clinically negligible' RKF compared with those with no RKF. The hemodialysis study excluded patients with urinary urea clearance >1.5 mL/min, below which RKF was considered to be 'clinically negligible'. We measured eight nonurea solutes from 1280 patients participating in this study and calculated the relative difference in solute levels among patients with and without RKF based on measured urinary urea clearance. Results: The mean age of the participants was 57 years and 57% were female. At baseline, 34% of the included participants had clinically negligible RKF (mean 0.7 ± 0.4 mL/min) and 66% had no RKF. Seven of the eight nonurea solute levels measured were significantly lower in patients with RKF than in those without RKF, ranging from -24% [95% confidence interval (CI) -31 to -16] for hippurate, -7% (-14 to -1) for trimethylamine-N-oxide and -4% (-6 to -1) for asymmetric dimethylarginine. The effect of RKF on plasma levels was comparable or more pronounced than that achieved with a 31% higher dialysis dose (spKt/Vurea 1.7 versus 1.3). Preserved RKF at 1-year follow-up was associated with a lower risk of cardiac death and first cardiovascular event. Conclusions: Even at very low levels, RKF is not 'negligible', as it continues to provide nonurea solute clearance. Management of patients with RKF should consider these differences.

Original languageEnglish (US)
Pages (from-to)846-853
Number of pages8
JournalNephrology Dialysis Transplantation
Issue number5
StatePublished - May 1 2020


  • clearance
  • dialysis dose
  • ESRD
  • hemodialysis
  • uremic toxins

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


Dive into the research topics of 'Contribution of 'clinically negligible' residual kidney function to clearance of uremic solutes'. Together they form a unique fingerprint.

Cite this