TY - JOUR
T1 - Contrast-enhanced intravascular ultrasound
T2 - Combining morphology with activity-based assessment of plaque vulnerability
AU - Vavuranakis, Manolis
AU - Kakadiaris, Ioannis A.
AU - Papaioannou, Theodoros G.
AU - O'Malley, Sean M.
AU - Carlier, Stephane
AU - Naghavi, Morteza
AU - Stefanadis, Christodoulos
N1 - Funding Information:
Theodoros G Papaioannou, PhD National Kapodistrian University of Athens, First Department of Cardiology, Hippokration Hospital, Unit of Biomedical Engineering, Medical School, Athens, Greece theopap@mail.ntua.gr Sean M O’Malley, PhD University of Houston, Computational Biomedicine Lab, Department of Computer Science, Houston, TX, USA Stephane Carlier, PhD, MD Cardiovascular Research Foundation, New York, NY, USA Tel.: +1 212 851 9371 Fax: +1212 851 9330 scarlier@crf.org Morteza Naghavi, MD Association for Eradication of Heart Attack, Houston, TX, USA Morteza.Naghavi@in3v.com Christodoulos Stefanadis, MD National Kapodistrian University of Athens, First Department of Cardiology, Hippokration Hospital, Medical School, Athens, Greece
PY - 2007/9
Y1 - 2007/9
N2 - Acute coronary syndromes are the result of coronary plaque rupture in the majority of cases. Available diagnostic techniques that focus on the early detection of plaques that are prone to rupture are still limited. Increased neovascularization in the vasa vasorum of the atherosclerotic plaque has been identified recently as a common feature of inflammation and plaque vulnerability. Microbubbles, which have been used for ultrasound imaging, can be used to trace neovascularization. We present recent advances in contrast agents and contrast-enhanced intravascular ultrasound that may be used for the detection of vasa vasorum, including fundamental and harmonic contrast imaging. Identification of vasa vasorum proliferation in atherosclerotic plaques presents important clinical implications; in particular it could provide a means to detect vulnerability in vivo, thereby guiding targeted treatments.
AB - Acute coronary syndromes are the result of coronary plaque rupture in the majority of cases. Available diagnostic techniques that focus on the early detection of plaques that are prone to rupture are still limited. Increased neovascularization in the vasa vasorum of the atherosclerotic plaque has been identified recently as a common feature of inflammation and plaque vulnerability. Microbubbles, which have been used for ultrasound imaging, can be used to trace neovascularization. We present recent advances in contrast agents and contrast-enhanced intravascular ultrasound that may be used for the detection of vasa vasorum, including fundamental and harmonic contrast imaging. Identification of vasa vasorum proliferation in atherosclerotic plaques presents important clinical implications; in particular it could provide a means to detect vulnerability in vivo, thereby guiding targeted treatments.
KW - ACES™
KW - Contrast-enhanced intravascular ultrasound
KW - Harmonic IVUS
KW - Image analysis
KW - Microbubbles
KW - Neovascularization
KW - Vasa vasorum
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U2 - 10.1586/14779072.5.5.917
DO - 10.1586/14779072.5.5.917
M3 - Review article
C2 - 17867921
AN - SCOPUS:34848920822
VL - 5
SP - 917
EP - 925
JO - Expert Review of Cardiovascular Therapy
JF - Expert Review of Cardiovascular Therapy
SN - 1477-9072
IS - 5
ER -