Contemporary Treatment Approaches to Sinonasal Mucosal Melanoma

Moran Amit, Shorook Na’ara, Ehab Y. Hanna

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Sinonasal mucosal melanoma (SNMM) is a rare oncological entity that comprises most head and neck mucosal melanomas. SNMM has distinctive genetic background, different from cutaneous melanoma. Survival outcomes among SNMM patients are poor; while there is no clear consensus on the optimal management of SNMM, the primary treatment modality is generally considered to be wide surgical excision, and radiation therapy (RT) is often used in the postoperative adjuvant setting to improve locoregional control. Systemic therapies have demonstrated little or no survival benefit, and most SNMM patients die of distant metastatic disease. Owing to the rarity of the disease, the literature describing treatment approaches for SNMM is lacking and largely limited to isolated case reports and retrospective series. Here, we describe contemporary diagnostic and therapeutic approaches to SNMM based on the most recent molecular and outcome data.

Original languageEnglish (US)
Article number10
JournalCurrent Oncology Reports
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • Distant metastasis
  • Melanoma
  • NRAS
  • Radiation
  • Sinonasal
  • Skull base

ASJC Scopus subject areas

  • Oncology

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