Conserved sequence analysis of influenza a virus ha segment and its application in rapid typing

Qianyu Lin, Xiang Ji, Feng Wu, Lan Ma

Research output: Contribution to journalArticlepeer-review

Abstract

The high mutation rate of the influenza A virus hemagglutinin segment poses great challenges to its long-term effective testing and subtyping. Our conserved sequence searching method achieves high-specificity conserved sequences on H1–H9 subtypes. In addition, PCR experiments show that primers based on conserved sequences can be used in influenza A virus HA subtyping. Conserved sequence-based primers are expected to be long-term, effective subtyping tools for influenza A virus HA.

Original languageEnglish (US)
Article number1328
JournalDiagnostics
Volume11
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • Conserved sequence
  • Influenza
  • Multiple sequence alignment
  • Rapid detection

ASJC Scopus subject areas

  • Clinical Biochemistry

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