Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase

Ling Qin, Martyn A. Sharpe, R. Michael Garavito, Shelagh Ferguson-Miller

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Specific interactions between lipids and membrane proteins have been observed in recent high-resolution crystal structures of membrane proteins. A number of cytochrome oxidase structures were analyzed, along with many amino acid sequences of membrane-spanning regions aligned according to their location in the membrane. The results reveal conservation of lipid-binding sites and of the residues that form them. These studies imply that bound lipids have important roles that are crucial to the assembly, structure, or activity of the protein. Evidence for some of these roles in subunit interactions, membrane insertion, and protein-protein complex formation is reviewed.

Original languageEnglish (US)
Pages (from-to)444-450
Number of pages7
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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