TY - JOUR
T1 - Conservative surgery in early-stage cervical cancer
T2 - What percentage of patients may be eligible for conization and lymphadenectomy?
AU - Smith, Ashlee L.
AU - Frumovitz, Michael
AU - Schmeler, Kathleen M.
AU - Reis, Ricardo Dos
AU - Nick, Alpa M.
AU - Coleman, Robert L.
AU - Ramirez, Pedro T.
PY - 2010/11
Y1 - 2010/11
N2 - Objective: To determine the proportion of young patients with early-stage invasive cervical cancer treated with radical hysterectomy who may have been eligible for fertility-sparing surgery consisting of cervical conization with pelvic lymph node dissection. Methods: We retrospectively identified all patients with early-stage cervical cancer (stages IA1-IB1) who underwent a radical hysterectomy at The University of Texas M. D. Anderson Cancer Center between 1990 and 2009. We reviewed these patients' records to identify patients who were < 40 years who had not previously undergone tubal ligation and who would have been considered candidates for cold-knife conization with pelvic lymph node dissection-i.e., women with tumors smaller than 2 cm, low-risk histology (squamous, adenocarcinoma, or adenosquamous), and no lymphovascular space invasion (LVSI). Results: A total of 507 patients with early-stage cervical cancer were identified who underwent radical hysterectomy during the review period. Of these women, 277 (55%) were 40 years or younger. Of these 277 patients, 75 (27%) had had a previous tubal ligation and 202 (73%) had not. Of these 202 patients potentially interested in fertility preserving surgery, 53 (26%) had favorable pathologic characteristics including low-risk histology, tumors ≤ 2 cm in size and no LVSI present. Of these 53 patients, none had parametrial involvement or positive lymph nodes. Conclusion: Among 202 women with age younger than 40 years and no previous tubal ligation who underwent radical hysterectomy, 53 (26%) may have been eligible for fertility-sparing surgery such as cold-knife conization with pelvic lymph node dissection.
AB - Objective: To determine the proportion of young patients with early-stage invasive cervical cancer treated with radical hysterectomy who may have been eligible for fertility-sparing surgery consisting of cervical conization with pelvic lymph node dissection. Methods: We retrospectively identified all patients with early-stage cervical cancer (stages IA1-IB1) who underwent a radical hysterectomy at The University of Texas M. D. Anderson Cancer Center between 1990 and 2009. We reviewed these patients' records to identify patients who were < 40 years who had not previously undergone tubal ligation and who would have been considered candidates for cold-knife conization with pelvic lymph node dissection-i.e., women with tumors smaller than 2 cm, low-risk histology (squamous, adenocarcinoma, or adenosquamous), and no lymphovascular space invasion (LVSI). Results: A total of 507 patients with early-stage cervical cancer were identified who underwent radical hysterectomy during the review period. Of these women, 277 (55%) were 40 years or younger. Of these 277 patients, 75 (27%) had had a previous tubal ligation and 202 (73%) had not. Of these 202 patients potentially interested in fertility preserving surgery, 53 (26%) had favorable pathologic characteristics including low-risk histology, tumors ≤ 2 cm in size and no LVSI present. Of these 53 patients, none had parametrial involvement or positive lymph nodes. Conclusion: Among 202 women with age younger than 40 years and no previous tubal ligation who underwent radical hysterectomy, 53 (26%) may have been eligible for fertility-sparing surgery such as cold-knife conization with pelvic lymph node dissection.
KW - Cervical cancer
KW - Conization
KW - Fertility preservation
KW - Radical trachelectomy
UR - http://www.scopus.com/inward/record.url?scp=77957737809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957737809&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2010.07.015
DO - 10.1016/j.ygyno.2010.07.015
M3 - Article
C2 - 20708227
AN - SCOPUS:77957737809
SN - 0090-8258
VL - 119
SP - 183
EP - 186
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 2
ER -