TY - JOUR
T1 - Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease
AU - Dong, Jie
AU - Hawes, Sarah
AU - Wu, Junbing
AU - Le, Weidong
AU - Cai, Huaibin
N1 - Funding Information:
This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health (AG000959 and AG000945).
Publisher Copyright:
© Copyright © 2021 Dong, Hawes, Wu, Le and Cai.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3/2
Y1 - 2021/3/2
N2 - The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for processing motor and non-motor information through the creation of complex connections with the other basal ganglia nuclei and brain regions. Recently, with the adoption of sophisticated genetic tools, substantial advances have been made in understanding the distinct molecular, anatomical, electrophysiological, and functional properties of GPe neurons and non-neuronal cells. Impairments in dopamine transmission in the basal ganglia contribute to Parkinson's disease (PD), the most common movement disorder that severely affects the patients' life quality. Altered GPe neuron activity and synaptic connections have also been found in both PD patients and pre-clinical models. In this review, we will summarize the main findings on the composition, connectivity and functionality of different GPe cell populations and the potential GPe-related mechanisms of PD symptoms to better understand the cell type and circuit-specific roles of GPe in both normal and PD conditions.
AB - The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for processing motor and non-motor information through the creation of complex connections with the other basal ganglia nuclei and brain regions. Recently, with the adoption of sophisticated genetic tools, substantial advances have been made in understanding the distinct molecular, anatomical, electrophysiological, and functional properties of GPe neurons and non-neuronal cells. Impairments in dopamine transmission in the basal ganglia contribute to Parkinson's disease (PD), the most common movement disorder that severely affects the patients' life quality. Altered GPe neuron activity and synaptic connections have also been found in both PD patients and pre-clinical models. In this review, we will summarize the main findings on the composition, connectivity and functionality of different GPe cell populations and the potential GPe-related mechanisms of PD symptoms to better understand the cell type and circuit-specific roles of GPe in both normal and PD conditions.
KW - Parkinson's disease
KW - arkypallidal neurons
KW - basal ganglia
KW - dopaminergic neurons
KW - glia
KW - globus pallidus externa
KW - prototypic neurons
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U2 - 10.3389/fncir.2021.645287
DO - 10.3389/fncir.2021.645287
M3 - Review article
AN - SCOPUS:85102863643
VL - 15
JO - Frontiers in Neural Circuits
JF - Frontiers in Neural Circuits
SN - 1662-5110
M1 - 645287
ER -