Confirmation of paternal disomy in a twin molar pregnancy: A case report

Brian Kirshon, Alexander Reiter, Karolina Adam, Sau W. Cheung

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Paternal dispermy can be the pathogenesis of complete molar pregnancy. CASE: A 23-year-old, white woman, gravida 4, para 1, was pregnant with a twin gestation by ovulation induction with metrodin. Ultrasound evaluation confirmed an intrauterine pregnancy in conjunction with what appeared to be a hydatidiform mole. The karyotype in the molar pregnancy, obtained from chorionic villus sampling, showed a pair of paternally derived inverted chromosomes 9, confirming the diagnosis of a complete mole. Uncontrollable hemorrhage with a rapid rise in the β-human chorionic gonadotropin titer necessitated evacuation of the uterus. The patient was followed with β-human chorionic gonadotropin titers for a year, with no evidence of recurrence. CONCLUSION: This case illustrates paternal disomy in a complete molar pregnancy documented by a paternal chromosome 9 inversion.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number1
StatePublished - Jan 1 2000


  • Hydatidiform mole
  • Inversion (genetics)
  • Ovulation induction
  • Prenatal diagnosis
  • Uniparental disomy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


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