Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study

Anatolio B. Cruz; Matilda Perkins; J. Bradley Aust; Charles A. Coltman; Ester B. Pollard; William S. Fletcher; Peter Kennedy; Daniel E. Lehane; Joaquin Mira; Joseph D. McCracken; Stephen D. Sorgen; Carey P. Page; Olga J. Pendleton; Eashwer Reddy; Joan Sapp; Frank Smith

doi:10.1002/jso.2930200410

Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study

Anatolio B. Cruz, Matilda Perkins, J. Bradley Aust, Charles A. Coltman, Ester B. Pollard, William S. Fletcher, Peter Kennedy, Daniel E. Lehane, Joaquin Mira, Joseph D. McCracken, Stephen D. Sorgen, Carey P. Page, Olga J. Pendleton, Eashwer Reddy, Joan Sapp, Frank Smith

Charles W. Duncan Jr. Department of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.

Original language	English (US)
Pages (from-to)	233-237
Number of pages	5
Journal	Journal of Surgical Oncology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1002/jso.2930200410
State	Published - Aug 1982

Keywords

bleomycin
chemotherapy
head and neck cancer
hydroxyurea

ASJC Scopus subject areas

Surgery
Oncology

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Cruz, A. B., Perkins, M., Aust, J. B., Coltman, C. A., Pollard, E. B., Fletcher, W. S., Kennedy, P., Lehane, D. E., Mira, J., McCracken, J. D., Sorgen, S. D., Page, C. P., Pendleton, O. J., Reddy, E., Sapp, J., & Smith, F. (1982). Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study. Journal of Surgical Oncology, 20(4), 233-237. https://doi.org/10.1002/jso.2930200410

Cruz, AB, Perkins, M, Aust, JB, Coltman, CA, Pollard, EB, Fletcher, WS, Kennedy, P, Lehane, DE, Mira, J, McCracken, JD, Sorgen, SD, Page, CP, Pendleton, OJ, Reddy, E, Sapp, J & Smith, F 1982, 'Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study', Journal of Surgical Oncology, vol. 20, no. 4, pp. 233-237. https://doi.org/10.1002/jso.2930200410

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title = "Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study",

abstract = "Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50\% (P = .47), and complete plus partial responses ranged from 57 to 84\% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.",

keywords = "bleomycin, chemotherapy, head and neck cancer, hydroxyurea",

author = "Cruz, \{Anatolio B.\} and Matilda Perkins and Aust, \{J. Bradley\} and Coltman, \{Charles A.\} and Pollard, \{Ester B.\} and Fletcher, \{William S.\} and Peter Kennedy and Lehane, \{Daniel E.\} and Joaquin Mira and McCracken, \{Joseph D.\} and Sorgen, \{Stephen D.\} and Page, \{Carey P.\} and Pendleton, \{Olga J.\} and Eashwer Reddy and Joan Sapp and Frank Smith",

year = "1982",

month = aug,

doi = "10.1002/jso.2930200410",

language = "English (US)",

volume = "20",

pages = "233--237",

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T2 - A southwest oncology group study

AU - Cruz, Anatolio B.

AU - Perkins, Matilda

AU - Aust, J. Bradley

AU - Coltman, Charles A.

AU - Pollard, Ester B.

AU - Fletcher, William S.

AU - Kennedy, Peter

AU - Lehane, Daniel E.

AU - Mira, Joaquin

AU - McCracken, Joseph D.

AU - Sorgen, Stephen D.

AU - Page, Carey P.

AU - Pendleton, Olga J.

AU - Reddy, Eashwer

AU - Sapp, Joan

AU - Smith, Frank

PY - 1982/8

Y1 - 1982/8

N2 - Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.

AB - Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.

KW - bleomycin

KW - chemotherapy

KW - head and neck cancer

KW - hydroxyurea

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JO - Journal of Surgical Oncology

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Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study

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