Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study

Anatolio B. Cruz, Matilda Perkins, J. Bradley Aust, Charles A. Coltman, Ester B. Pollard, William S. Fletcher, Peter Kennedy, Daniel E. Lehane, Joaquin Mira, Joseph D. McCracken, Stephen D. Sorgen, Carey P. Page, Olga J. Pendleton, Eashwer Reddy, Joan Sapp, Frank Smith

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalJournal of Surgical Oncology
Volume20
Issue number4
DOIs
StatePublished - Aug 1982

Keywords

  • bleomycin
  • chemotherapy
  • head and neck cancer
  • hydroxyurea

ASJC Scopus subject areas

  • Surgery
  • Oncology

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