Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

William J. Griffiths; Jonas Abdel-Khalik; Eylan Yutuc; Gustavo C. Roman; Margaret Warner; Jan Åke Gustafsson; Yuqin Wang

doi:10.1016/j.freeradbiomed.2018.12.020

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

William J. Griffiths, Jonas Abdel-Khalik, Eylan Yutuc, Gustavo C. Roman, Margaret Warner, Jan Åke Gustafsson, Yuqin Wang

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

Original language	English (US)
Pages (from-to)	42-52
Number of pages	11
Journal	Free Radical Biology and Medicine
Volume	134
DOIs	https://doi.org/10.1016/j.freeradbiomed.2018.12.020
State	Published - Apr 2019

Keywords

Bile acid
Brain
Cholestenoic acid
Cholesterol
Mass spectrometry, Cytochrome P450
Neurodegenerative disease
Oxysterol
Sterol

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

Access to Document

10.1016/j.freeradbiomed.2018.12.020

Cite this

@article{9c9f8c22539847b99b85181923245fa2,

title = "Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients",

abstract = "Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.",

keywords = "Bile acid, Brain, Cholestenoic acid, Cholesterol, Mass spectrometry, Cytochrome P450, Neurodegenerative disease, Oxysterol, Sterol",

author = "Griffiths, \{William J.\} and Jonas Abdel-Khalik and Eylan Yutuc and Roman, \{Gustavo C.\} and Margaret Warner and Gustafsson, \{Jan {\AA}ke\} and Yuqin Wang",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2019",

month = apr,

doi = "10.1016/j.freeradbiomed.2018.12.020",

language = "English (US)",

volume = "134",

pages = "42--52",

journal = "Free Radical Biology and Medicine",

issn = "0891-5849",

publisher = "Elsevier",

}

TY - JOUR

T1 - Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

AU - Griffiths, William J.

AU - Abdel-Khalik, Jonas

AU - Yutuc, Eylan

AU - Roman, Gustavo C.

AU - Warner, Margaret

AU - Gustafsson, Jan Åke

AU - Wang, Yuqin

PY - 2019/4

Y1 - 2019/4

N2 - Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

AB - Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

KW - Bile acid

KW - Brain

KW - Cholestenoic acid

KW - Cholesterol

KW - Mass spectrometry, Cytochrome P450

KW - Neurodegenerative disease

KW - Oxysterol

KW - Sterol

UR - https://www.scopus.com/pages/publications/85059540150

UR - https://www.scopus.com/inward/citedby.url?scp=85059540150&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2018.12.020

DO - 10.1016/j.freeradbiomed.2018.12.020

M3 - Article

C2 - 30578919

AN - SCOPUS:85059540150

SN - 0891-5849

VL - 134

SP - 42

EP - 52

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this