TY - JOUR
T1 - Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
AU - Griffiths, William J.
AU - Abdel-Khalik, Jonas
AU - Yutuc, Eylan
AU - Roman, Gustavo C.
AU - Warner, Margaret
AU - Gustafsson, Jan Åke
AU - Wang, Yuqin
PY - 2019/4
Y1 - 2019/4
N2 - Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.
AB - Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.
KW - Bile acid
KW - Brain
KW - Cholestenoic acid
KW - Cholesterol
KW - Mass spectrometry, Cytochrome P450
KW - Neurodegenerative disease
KW - Oxysterol
KW - Sterol
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UR - http://www.scopus.com/inward/citedby.url?scp=85059540150&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2018.12.020
DO - 10.1016/j.freeradbiomed.2018.12.020
M3 - Article
C2 - 30578919
AN - SCOPUS:85059540150
VL - 134
SP - 42
EP - 52
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
SN - 0891-5849
ER -