@article{9c9f8c22539847b99b85181923245fa2,
title = "Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients",
abstract = "Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.",
keywords = "Bile acid, Brain, Cholestenoic acid, Cholesterol, Mass spectrometry, Cytochrome P450, Neurodegenerative disease, Oxysterol, Sterol",
author = "Griffiths, {William J.} and Jonas Abdel-Khalik and Eylan Yutuc and Roman, {Gustavo C.} and Margaret Warner and Gustafsson, {Jan {\AA}ke} and Yuqin Wang",
note = "Funding Information: This work was supported by the UK Biotechnology and Biological Sciences Research Council (BBSRC, grant numbers BB/I001735/1 and BB/N015932/1 to WJG, BB/L001942/1 to YW), an Engineering and Physical Sciences Research Council Impact Acceleration Account (to Swansea University), the Welsh Government ( A4B grant to WJG and YW), the Swedish Science Council (grant to J{\AA}G) and the Robert A. Welch Fund (Grant E-0004 to J{\AA}G). JAK was supported by a Ph.D. studentship from Imperial College Healthcare Charities . Members of the European Network for Oxysterol Research (ENOR, https://www.oxysterols.net/ ) are thanked for informative discussions. Publisher Copyright: {\textcopyright} 2018 The Authors Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = apr,
doi = "10.1016/j.freeradbiomed.2018.12.020",
language = "English (US)",
volume = "134",
pages = "42--52",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier",
}