Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

William J. Griffiths; Jonas Abdel-Khalik; Eylan Yutuc; Gustavo C. Roman; Margaret Warner; Jan Åke Gustafsson; Yuqin Wang

doi:10.1016/j.freeradbiomed.2018.12.020

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

William J. Griffiths, Jonas Abdel-Khalik, Eylan Yutuc, Gustavo C. Roman, Margaret Warner, Jan Åke Gustafsson, Yuqin Wang

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

Original language	English (US)
Pages (from-to)	42-52
Number of pages	11
Journal	Free Radical Biology and Medicine
Volume	134
DOIs	https://doi.org/10.1016/j.freeradbiomed.2018.12.020
State	Published - Apr 2019

Keywords

Bile acid
Brain
Cholestenoic acid
Cholesterol
Mass spectrometry, Cytochrome P450
Neurodegenerative disease
Oxysterol
Sterol

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

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10.1016/j.freeradbiomed.2018.12.020

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title = "Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients",

abstract = "Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.",

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AU - Griffiths, William J.

AU - Abdel-Khalik, Jonas

AU - Yutuc, Eylan

AU - Roman, Gustavo C.

AU - Warner, Margaret

AU - Gustafsson, Jan Åke

AU - Wang, Yuqin

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N2 - Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

AB - Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

KW - Bile acid

KW - Brain

KW - Cholestenoic acid

KW - Cholesterol

KW - Mass spectrometry, Cytochrome P450

KW - Neurodegenerative disease

KW - Oxysterol

KW - Sterol

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ER -

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

Abstract

Keywords

ASJC Scopus subject areas

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