Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

William J. Griffiths, Jonas Abdel-Khalik, Eylan Yutuc, Gustavo C. Roman, Margaret Warner, Jan Åke Gustafsson, Yuqin Wang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

Original languageEnglish (US)
Pages (from-to)42-52
Number of pages11
JournalFree Radical Biology and Medicine
Volume134
DOIs
StatePublished - Apr 2019

Keywords

  • Bile acid
  • Brain
  • Cholestenoic acid
  • Cholesterol
  • Mass spectrometry, Cytochrome P450
  • Neurodegenerative disease
  • Oxysterol
  • Sterol

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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