Computer-controlled electrical stimulation for quantitative mapping of human cortical function: Technical note

Mario F. Dulay, Dona K. Murphey, Ping Sun, Yadin B. David, John H.R. Maunsell, Michael S. Beauchamp, Daniel Yoshor

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Cortical mapping with electrical stimulation (ES) in neurosurgical patients typically involves the manually controlled delivery of suprathreshold electrical current to a discrete area of the brain. Limited numbers of trials and imprecise current delivery methods increase the variability of the behavioral response and make it difficult to collect quantitative mapping data, which is especially important in research studies of human cortical function. To overcome these limitations, the authors developed a method for computer-controlled delivery of defined electrical current to implanted intracranial electrodes. They demonstrate that stimulation can be time locked to a behavioral task to rapidly and systematically measure the detection threshold for ES in human visual cortex over many trials. Computer-controlled ES is well suited for the systematic and quantitative study of the function of virtually any region of cerebral cortex. It may be especially useful for studying human cortical regions that are not well characterized and for verifying the presence of stimulation-evoked percepts that are difficult to objectively confirm.

Original languageEnglish (US)
Pages (from-to)1300-1303
Number of pages4
JournalJournal of Neurosurgery
Issue number6
StatePublished - Jun 2009


  • Computer-controlled electrical stimulation
  • Cortical electrical stimulation
  • Psychophysics

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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