Computed Tomography–Derived 3D Modeling to Guide Sizing and Planning of Transcatheter Mitral Valve Interventions

Joris F. Ooms, Dee Dee Wang, Ronak Rajani, Simon Redwood, Stephen H. Little, Michael L. Chuang, Jeffrey J. Popma, Gry Dahle, Michael Pfeiffer, Brinder Kanda, Magali Minet, Alexander Hirsch, Ricardo P. Budde, Peter P. De Jaegere, Bernard Prendergast, William O'Neill, Nicolas M. Van Mieghem

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


A plethora of catheter-based strategies have been developed to treat mitral valve disease. Evolving 3-dimensional (3D) multidetector computed tomography (MDCT) technology can accurately reconstruct the mitral valve by means of 3-dimensional computational modeling (3DCM) to allow virtual implantation of catheter-based devices. 3D printing complements computational modeling and offers implanting physician teams the opportunity to evaluate devices in life-size replicas of patient-specific cardiac anatomy. MDCT-derived 3D computational and 3D-printed modeling provides unprecedented insights to facilitate hands-on procedural planning, device training, and retrospective procedural evaluation. This overview summarizes current concepts and provides insight into the application of MDCT-derived 3DCM and 3D printing for the planning of transcatheter mitral valve replacement and closure of paravalvular leaks. Additionally, future directions in the development of 3DCM will be discussed.

Original languageEnglish (US)
Pages (from-to)1644-1658
Number of pages15
JournalJACC: Cardiovascular Imaging
Issue number8
StatePublished - Aug 2021


  • 3D printing
  • computational modeling
  • mitral annular calcification
  • multidetector computed tomography
  • paravalvular leakage closure
  • transcatheter mitral valve replacement
  • Multidetector Computed Tomography
  • Predictive Value of Tests
  • Heart Valve Prosthesis
  • Humans
  • Mitral Valve/diagnostic imaging
  • Retrospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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