Computational whole-body-exposome models for global precision brain health

Agustín Ibáñez; Claudia Duran-Aniotz; Joaquín Migeot; Sandra Báez; Sol Fittipaldi; Carlos Coronel-Oliveros; Harris A. Eyre; Chinedu Udeh-Momoh; Henrik Zetterberg; Suvarna Alladi; Carmen Sandi; Ian H. Robertson; Sanne Franzen; Temitope Farombi; Janitza L. Montalvo Ortiz; Sudha Seshadri; Felipe Court; Pedro Valdes-Sosa; Jiayuan Xu; Chunshui Yu; Lea Grinberg; Brian Lawlor; Perminder S. Sachdev; Kristine Yaffe; Vladimir Hachinski; Karl Friston; Enzo Tagliazucchi; Hernando Santamaría-García

doi:10.1038/s41467-025-67448-3

Computational whole-body-exposome models for global precision brain health

Agustín Ibáñez, Claudia Duran-Aniotz, Joaquín Migeot, Sandra Báez, Sol Fittipaldi, Carlos Coronel-Oliveros, Harris A. Eyre, Chinedu Udeh-Momoh, Henrik Zetterberg, Suvarna Alladi, Carmen Sandi, Ian H. Robertson, Sanne Franzen, Temitope Farombi, Janitza L. Montalvo Ortiz, Sudha Seshadri, Felipe Court, Pedro Valdes-Sosa, Jiayuan Xu, Chunshui YuLea Grinberg, Brian Lawlor, Perminder S. Sachdev, Kristine Yaffe, Vladimir Hachinski, Karl Friston, Enzo Tagliazucchi, Hernando Santamaría-García

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The worldwide rise of neurological and psychiatric conditions poses major challenges. However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body health, exposome, and brain health. Theories rarely unify brain measures with extracerebral factors or capture heterogeneity in individual trajectories. We introduce multimodal diversity, a non-linear, non-simplistic causal and ecological construct integrating data representation, whole-body and exposomic factors, and computational modeling to address this situated, embedded, and embodied complexity. This heuristic metamodel integrates global, multilevel data into personalized predictions fostering population inclusion, multimodal integration, diagnostic precision, and equitable, context-sensitive advances in brain health.

Original language	English (US)
Article number	11078
Journal	Nature Communications
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/s41467-025-67448-3
State	Published - Dec 2025

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General
General Physics and Astronomy

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10.1038/s41467-025-67448-3

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Ibáñez, A., Duran-Aniotz, C., Migeot, J., Báez, S., Fittipaldi, S., Coronel-Oliveros, C., Eyre, H. A., Udeh-Momoh, C., Zetterberg, H., Alladi, S., Sandi, C., Robertson, I. H., Franzen, S., Farombi, T., Montalvo Ortiz, J. L., Seshadri, S., Court, F., Valdes-Sosa, P., Xu, J., ... Santamaría-García, H. (2025). Computational whole-body-exposome models for global precision brain health. Nature Communications, 16(1), Article 11078. https://doi.org/10.1038/s41467-025-67448-3

Ibáñez, A, Duran-Aniotz, C, Migeot, J, Báez, S, Fittipaldi, S, Coronel-Oliveros, C, Eyre, HA, Udeh-Momoh, C, Zetterberg, H, Alladi, S, Sandi, C, Robertson, IH, Franzen, S, Farombi, T, Montalvo Ortiz, JL, Seshadri, S, Court, F, Valdes-Sosa, P, Xu, J, Yu, C, Grinberg, L, Lawlor, B, Sachdev, PS, Yaffe, K, Hachinski, V, Friston, K, Tagliazucchi, E & Santamaría-García, H 2025, 'Computational whole-body-exposome models for global precision brain health', Nature Communications, vol. 16, no. 1, 11078. https://doi.org/10.1038/s41467-025-67448-3

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abstract = "The worldwide rise of neurological and psychiatric conditions poses major challenges. However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body health, exposome, and brain health. Theories rarely unify brain measures with extracerebral factors or capture heterogeneity in individual trajectories. We introduce multimodal diversity, a non-linear, non-simplistic causal and ecological construct integrating data representation, whole-body and exposomic factors, and computational modeling to address this situated, embedded, and embodied complexity. This heuristic metamodel integrates global, multilevel data into personalized predictions fostering population inclusion, multimodal integration, diagnostic precision, and equitable, context-sensitive advances in brain health.",

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AU - Ibáñez, Agustín

AU - Duran-Aniotz, Claudia

AU - Migeot, Joaquín

AU - Báez, Sandra

AU - Fittipaldi, Sol

AU - Coronel-Oliveros, Carlos

AU - Eyre, Harris A.

AU - Udeh-Momoh, Chinedu

AU - Zetterberg, Henrik

AU - Alladi, Suvarna

AU - Sandi, Carmen

AU - Robertson, Ian H.

AU - Franzen, Sanne

AU - Farombi, Temitope

AU - Montalvo Ortiz, Janitza L.

AU - Seshadri, Sudha

AU - Court, Felipe

AU - Valdes-Sosa, Pedro

AU - Xu, Jiayuan

AU - Yu, Chunshui

AU - Grinberg, Lea

AU - Lawlor, Brian

AU - Sachdev, Perminder S.

AU - Yaffe, Kristine

AU - Hachinski, Vladimir

AU - Friston, Karl

AU - Tagliazucchi, Enzo

AU - Santamaría-García, Hernando

PY - 2025/12

Y1 - 2025/12

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AB - The worldwide rise of neurological and psychiatric conditions poses major challenges. However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body health, exposome, and brain health. Theories rarely unify brain measures with extracerebral factors or capture heterogeneity in individual trajectories. We introduce multimodal diversity, a non-linear, non-simplistic causal and ecological construct integrating data representation, whole-body and exposomic factors, and computational modeling to address this situated, embedded, and embodied complexity. This heuristic metamodel integrates global, multilevel data into personalized predictions fostering population inclusion, multimodal integration, diagnostic precision, and equitable, context-sensitive advances in brain health.

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Computational whole-body-exposome models for global precision brain health

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