TY - JOUR
T1 - Compression and free expansion of single DNA molecules in nanochannels
AU - Reccius, Christian Hermann
AU - Mannion, John Thomas
AU - Cross, Joshua David
AU - Craighead, H. G.
PY - 2005/12/31
Y1 - 2005/12/31
N2 - We investigated compression and ensuing expansion of long DNA molecules confined in nanochannels. Transverse confinement of DNA molecules in the nanofluidic channels leads to elongation of their unconstrained equilibrium configuration. The extended molecules were compressed by electrophoretically driving them into porelike constrictions inside the nanochannels. When the electric field was turned off, the DNA strands expanded. This expansion, the dynamics of which has not previously been observable in artificial systems, is explained by a model that is a variation of de Gennes's polymer model.
AB - We investigated compression and ensuing expansion of long DNA molecules confined in nanochannels. Transverse confinement of DNA molecules in the nanofluidic channels leads to elongation of their unconstrained equilibrium configuration. The extended molecules were compressed by electrophoretically driving them into porelike constrictions inside the nanochannels. When the electric field was turned off, the DNA strands expanded. This expansion, the dynamics of which has not previously been observable in artificial systems, is explained by a model that is a variation of de Gennes's polymer model.
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U2 - 10.1103/PhysRevLett.95.268101
DO - 10.1103/PhysRevLett.95.268101
M3 - Article
C2 - 16486410
AN - SCOPUS:30344436391
SN - 0031-9007
VL - 95
JO - Physical Review Letters
JF - Physical Review Letters
IS - 26
M1 - 268101
ER -