TY - JOUR
T1 - Comprehensive and combined omics analysis reveals factors of ischemia-reperfusion injury in liver transplantation
AU - Huang, Shanzhou
AU - Ju, Weiqiang
AU - Zhu, Zebin
AU - Han, Ming
AU - Sun, Chengjun
AU - Tang, Yunhua
AU - Hou, Yuchen
AU - Zhang, Zhiheng
AU - Yang, Jie
AU - Zhang, Yixi
AU - Wang, Linhe
AU - Lin, Fanxiong
AU - Chen, Haitian
AU - Xie, Rongxing
AU - Zhu, Caihui
AU - Wang, Dongping
AU - Wu, Linwei
AU - Zhao, Qiang
AU - Chen, Maogen
AU - Zhou, Qi
AU - Guo, Zhiyong
AU - He, Xiaoshun
N1 - Funding Information:
This study was supported by the following grants: the National Natural Science Foundation of China (81373156 and 81570587), the Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation; 2015B050501002), the Science and Technology Program of Guangzhou (201704020150) and the Science and Technology Program of Huizhou (170520181743174/2017Y229 and 180529101741637/2018Y305).
Funding Information:
This study was supported by the following grants: the National Natural Science Foundation of China (81373156 and 81570587), the Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation; 2015B050501002), the Science and Technology Program of Guangzhou (201704020150) and the Science and Technology Program of Huizhou (170520181743174/2017Y229 and 180529101741637/2018Y305). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2019 Future Medicine Ltd.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/4
Y1 - 2019/4
N2 - Aim: To explore molecular mechanisms underlying liver ischemia-reperfusion injury (IRI). Materials & methods: Four Gene Expression Omnibus datasets comprising liver transplantation data were collected for a comprehensive analysis. A proteomic analysis was performed and used for correlations analysis with transcriptomic. Results & conclusion: Ten differentially expressed genes were co-upregulated in four Gene Expression Omnibus datasets, including ATF3, CCL4, DNAJB1, DUSP5, JUND, KLF6, NFKBIA, PLAUR, PPP1R15A and TNFAIP3. The combined analysis demonstrated ten coregulated genes/proteins, including HBB, HBG2, CA1, SLC4A1, PLIN2, JUNB, HBA1, MMP9, SLC2A1 and PADI4. The coregulated differentially expressed genes and coregulated genes/proteins formed a tight interaction network and could serve as the core factors underlying IRI. Comprehensive and combined omics analyses revealed key factors underlying liver IRI, and thus having potential clinical significance.
AB - Aim: To explore molecular mechanisms underlying liver ischemia-reperfusion injury (IRI). Materials & methods: Four Gene Expression Omnibus datasets comprising liver transplantation data were collected for a comprehensive analysis. A proteomic analysis was performed and used for correlations analysis with transcriptomic. Results & conclusion: Ten differentially expressed genes were co-upregulated in four Gene Expression Omnibus datasets, including ATF3, CCL4, DNAJB1, DUSP5, JUND, KLF6, NFKBIA, PLAUR, PPP1R15A and TNFAIP3. The combined analysis demonstrated ten coregulated genes/proteins, including HBB, HBG2, CA1, SLC4A1, PLIN2, JUNB, HBA1, MMP9, SLC2A1 and PADI4. The coregulated differentially expressed genes and coregulated genes/proteins formed a tight interaction network and could serve as the core factors underlying IRI. Comprehensive and combined omics analyses revealed key factors underlying liver IRI, and thus having potential clinical significance.
KW - combined analysis
KW - comprehensive analysis
KW - ischemia-reperfusion injury
KW - liver transplantation
KW - proteome
KW - transcriptome
UR - http://www.scopus.com/inward/record.url?scp=85063612755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063612755&partnerID=8YFLogxK
U2 - 10.2217/epi-2018-0189
DO - 10.2217/epi-2018-0189
M3 - Article
C2 - 30700158
AN - SCOPUS:85063612755
VL - 11
SP - 527
EP - 542
JO - Epigenomics
JF - Epigenomics
SN - 1750-1911
IS - 5
ER -