@article{35008888967f469d8fdd271786149928,
title = "Compositional and functional features of the gastrointestinal microbiome and their effects on human health",
abstract = "The human gastrointestinal tract contains distinct microbial communities that differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host. We describe the bacterial taxa present in different locations of the GI tract, and their specific metabolic features. The distinct features of these specific microbial communities might affect human health and disease. Several bacterial taxa and metabolic modules (biochemical functions) have been associated with human health and the absence of disease. Core features of the healthy microbiome might be defined and targeted to prevent disease and optimize human health.",
keywords = "Gastrointestinal, HMP, Lumen, Metagenomics, Microbe, Mucosa",
author = "Hollister, {Emily B.} and Chunxu Gao and James Versalovic",
note = "Funding Information: The Human Microbiome Project, funded by the US National Institutes of Health, included a total of 300 subjects recruited from St. Louis and Houston. A total of 554 individuals were screened for inclusion in the study. Many criteria were considered in selecting the adults for the final cohort. 16 The mean age of these individuals was 26 years, and the mean body mass index was 24 kg/m 2 . Specimens were collected from a total of 18 body sites, but the human GI tract was represented by a single stool specimen, collected by each individual. Funding Information: Funding Supported in part by research support from the National Institutes of Health ( R01 AT004326 , UH3 DK083990 , and U01 CA170930 ); the National Institutes of Health (National Institute for Diabetes and Digestive and Kidney Diseases)-funded (DK56338) Texas Medical Center Digestive Diseases Center; and unrestricted research support from BioGaia AB (Stockholm, Sweden) (J.V.). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2014",
month = may,
doi = "10.1053/j.gastro.2014.01.052",
language = "English (US)",
volume = "146",
pages = "1449--1458",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6",
}