Composite scaffolds for bone and osteochondral defects

Vincenzo Guarino, Silvia Scaglione, Monica Sandri, Simone Sprio, Anna Tampieri, Luigi Ambrosio

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

The fast replacement of native functionality (i.e., biological, chemical, mechanical) of damaged skeletal tissues currently represents an important challenge of clinical surgery. Through an accurate study of natural tissues and biomimesis, advanced biomaterials can be designed in the form of porous scaffolds to create hierarchical porous structures with the desired mechanical performances and mass transport properties (permeability and diffusion) while reproducing the complex 3D anatomical shapes. Recently, bioinspired composite scaffolds have been successfully used for the regeneration of bone and osteochondral tissue due to their unique ability to accurately mimic tissue functions and organization at different size scale levels. As a function of the filler/matrix coupling, they may ensure biochemical affinity with the host tissue through a judicious mix of specific morphological and chemical cues, also mimicking the response under load exhibited by natural tissue through a complex organization of material phases.

Original languageEnglish (US)
Title of host publicationMaterials for Biomedical Engineering
Subtitle of host publicationHydrogels and Polymer-based Scaffolds
PublisherElsevier
Pages297-337
Number of pages41
ISBN (Electronic)9780128169018
DOIs
StatePublished - Jan 1 2019

Keywords

  • Biodegrabale matrices
  • Bioresorbable matrices
  • Collagen
  • Hydroxyapatite
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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