Compliance of Textile Vascular Prostheses Is a Fleeting Reality

Benoit Lucereau, Foued Koffhi, Anne Lejay, Yannick Georg, Bernard Durand, Fabien Thaveau, Frédéric Heim, Nabil Chakfe

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective: Compliance is considered to be a major property influencing the long term performances of synthetic vascular substitutes that could play a role in anastomotic false aneurysm and intimal hyperplasia stenosis onset. Over the last decades, manufacturers have tried to develop substitutes that mechanically mimic arterial properties and avoid a compliance mismatch at the anastomoses in particular. However, data are missing about how initial compliance properties could change with time. The goal of this study was to evaluate how the compliance of vascular grafts evolves under cyclic loading conditions in vitro. Methods: The compliance of three different models of commercially available textile polyethylene terephthalate (PET) grafts was evaluated. Tests were performed with and without their original coating. Compliance was assessed with a specific device dedicated to measure the deformations undergone by a graft under cyclic pressure loading conditions, using image analysis software. In each experiment, image analysis was performed under 60 and 140 mmHg pressure loading conditions at loading start (H0) and after three, six, and 24 h (H3, H6, H24) loading time. Average radial, longitudinal, and volumetric compliance was calculated from the obtained images. Results: Twenty-four samples were tested. Results demonstrate that all values decreased significantly within only a few hours. On average, the loss of compliance after 3 h of cyclic loading ranged on average from 35% for longitudinal compliance to 39% for radial compliance and 37% (p <.050) for volume compliance. After 24 h, the loss of radial, longitudinal and volume compliance was respectively 63 ± 3%, 60.5 ± 2% and 61 ± 7%. Conclusion: In this in vitro model, PET graft compliance has already decreased significantly within 3 h. The rapid loss of compliance identified in this experimental study helps explain the mismatch mentioned in clinical observations.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume60
Issue number5
DOIs
StatePublished - Nov 2020

Keywords

  • Compliance
  • Compliance evolution
  • Compliance mismatch
  • Vascular graft

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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