Complement sensing of nanoparticles and nanomedicines

Peter P. Wibroe, Seyed Moghimi

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Nanoparticles are being increasingly implemented in drug delivery and diagnostic systems, as they show promising features in protected, targeted and sustained delivery of active pharmaceutical ingredients and contrast agents. Following intravenous injection, nanoparticles, depending on their physicochemical properties, may trigger the complement system, which is a major part of the innate immune system. Complement activation and fixation can prime the surface of nanoparticles for rapid recognition and clearance by complement receptor bearing cells such as blood monocytes and macrophages of the reticuloendothelial system. Uncontrolled complement activation can also induce adverse reactions, and these have been reported with regulatory approved nanomedicines, including stealth therapeutics. We discuss on the interaction between the complement system and synthetic surfaces, and comment on general physicochemical parameters that incite complement. State-of-the-art approaches for evaluation and determination of complement activation and sensing are also described.

Original languageEnglish (US)
Title of host publicationFunctional Nanoparticles for Functional Nanoparticles for and Bioelectronic Deices
Subtitle of host publicationVolume 2
PublisherAmerican Chemical Society
Pages365-382
Number of pages18
ISBN (Print)9780841228283
DOIs
StatePublished - Nov 26 2012

Publication series

NameACS Symposium Series
Volume1113
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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