TY - JOUR
T1 - Complement propriety and conspiracy in nanomedicine
T2 - Perspective and a hypothesis
AU - Moghimi, Seyed Moein
N1 - Publisher Copyright:
© Mary Ann Liebert, Inc. 2016.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The complement system is the first line of body's defense against intruders and it acts as a functional bridge between innate and adaptive arms of the immune system. This commentary examines the key roles of complement activation in response to nanomedicine administration, including nucleic acid complexes. These comprise beneficial (eg, adjuvanticity) as well as adverse effects (eg, infusion-related reactions). Pigs (and sheep) are often used as predictive models of nanomedicine-mediated infusion-related reactions in humans. The validity of these models in relation to human responses is questioned, and an alternative hypothesis is presented.
AB - The complement system is the first line of body's defense against intruders and it acts as a functional bridge between innate and adaptive arms of the immune system. This commentary examines the key roles of complement activation in response to nanomedicine administration, including nucleic acid complexes. These comprise beneficial (eg, adjuvanticity) as well as adverse effects (eg, infusion-related reactions). Pigs (and sheep) are often used as predictive models of nanomedicine-mediated infusion-related reactions in humans. The validity of these models in relation to human responses is questioned, and an alternative hypothesis is presented.
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U2 - 10.1089/nat.2015.0587
DO - 10.1089/nat.2015.0587
M3 - Article
C2 - 26720796
AN - SCOPUS:84964452135
VL - 26
SP - 67
EP - 72
JO - Nucleic Acid Therapeutics
JF - Nucleic Acid Therapeutics
SN - 2159-3337
IS - 2
ER -