Complement propriety and conspiracy in nanomedicine: Perspective and a hypothesis

Seyed Moein Moghimi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The complement system is the first line of body's defense against intruders and it acts as a functional bridge between innate and adaptive arms of the immune system. This commentary examines the key roles of complement activation in response to nanomedicine administration, including nucleic acid complexes. These comprise beneficial (eg, adjuvanticity) as well as adverse effects (eg, infusion-related reactions). Pigs (and sheep) are often used as predictive models of nanomedicine-mediated infusion-related reactions in humans. The validity of these models in relation to human responses is questioned, and an alternative hypothesis is presented.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalNucleic Acid Therapeutics
Issue number2
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery


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