Complement activation by PEG-functionalized multi-walled carbon nanotubes is independent of PEG molecular mass and surface density

Alina J. Andersen, Barbara Windschiegl, Sibel Ilbasmis-Tamer, Ismail T. Degim, Alan Christy Hunter, Thomas L. Andresen, Seyed Moein Moghimi

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Carboxylated (4%) multi-walled carbon nanotubes were covalently functionalized with poly(ethylene glycol)1000 (PEG1000), PEG1500 and PEG4000 with a PEG loading of approximately 11% in all cases. PEG loading generated non-uniform and heterogeneous higher surface structures and increased nanotube width considerably, but all PEGylated nanotube species activated the complement system in human serum equally. Increased PEG loading, through adsorption of methoxyPEG2000(or 5000)-phospholipid conjugates, generated fewer complement activation products; however, complement activation was never completely eliminated. Our observations address the difficulty in making carbon nanotubes more compatible with innate immunity through covalent PEG functionalization as well as double PEGylation strategies.

Original languageEnglish (US)
Pages (from-to)469-473
Number of pages5
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume9
Issue number4
DOIs
StatePublished - May 2013

Keywords

  • Atomic force microscope
  • Carbon nanotubes
  • Complement system
  • Innate immunity
  • Poly(ethylene glycol)

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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