TY - JOUR
T1 - Comparison of toxicity values across zebrafish early life stages and mammalian studies
T2 - Implications for chemical testing
AU - Ducharme, Nicole A.
AU - Reif, David M.
AU - Gustafsson, Jan Ake
AU - Bondesson, Maria
N1 - Funding Information:
This study was funded by a grant from the United States Environmental Protection Agency (Grant # R834289 ) and performed within the Texas-Indiana Virtual STAR Center project. The views expressed in the article reflect the views of the authors and not necessarily the funder.
Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - With the high cost and slow pace of toxicity testing in mammals, the vertebrate zebrafish has become a tractable model organism for high throughput toxicity testing. We present here a meta-analysis of 600 chemicals tested for toxicity in zebrafish embryos and larvae. Nineteen aggregated and 57 individual toxicity endpoints were recorded from published studies yielding 2695 unique data points. These data points were compared to lethality and reproductive toxicology endpoints analyzed in rodents and rabbits and to exposure values for humans. We show that although many zebrafish endpoints did not correlate to rodent or rabbit acute toxicity data, zebrafish could be used to accurately predict relative acute toxicity through the rat inhalation, rabbit dermal, and rat oral exposure routes. Ranking of the chemicals based on toxicity and teratogenicity in zebrafish, as well as human exposure levels, revealed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene, and chlorpyrifos ranked in the top nine of all chemicals for these three categories, and as such should be considered high priority chemicals for testing in higher vertebrates.
AB - With the high cost and slow pace of toxicity testing in mammals, the vertebrate zebrafish has become a tractable model organism for high throughput toxicity testing. We present here a meta-analysis of 600 chemicals tested for toxicity in zebrafish embryos and larvae. Nineteen aggregated and 57 individual toxicity endpoints were recorded from published studies yielding 2695 unique data points. These data points were compared to lethality and reproductive toxicology endpoints analyzed in rodents and rabbits and to exposure values for humans. We show that although many zebrafish endpoints did not correlate to rodent or rabbit acute toxicity data, zebrafish could be used to accurately predict relative acute toxicity through the rat inhalation, rabbit dermal, and rat oral exposure routes. Ranking of the chemicals based on toxicity and teratogenicity in zebrafish, as well as human exposure levels, revealed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene, and chlorpyrifos ranked in the top nine of all chemicals for these three categories, and as such should be considered high priority chemicals for testing in higher vertebrates.
KW - Human exposure
KW - Meta-analysis
KW - Teratogen
KW - Toxicity
KW - Zebrafish
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U2 - 10.1016/j.reprotox.2014.09.005
DO - 10.1016/j.reprotox.2014.09.005
M3 - Article
C2 - 25261610
AN - SCOPUS:84939415843
SN - 0890-6238
VL - 55
SP - 3
EP - 10
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -