Comparison of the effect of radiation exposure from dual-energy CT versus single-energy CT on double-strand breaks at CT pulmonary angiography

Shu Min Tao, Xie Li, U. Joseph Schoepf, John W. Nance, Brian E. Jacobs, Chang Sheng Zhou, Hai Feng Gu, Meng Jie Lu, Guang Ming Lu, Long Jiang Zhang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: To compare the effect of dual-source dual-energy CT versus single-energy CT on DNA double-strand breaks (DSBs) in blood lymphocytes at CT pulmonary angiography (CTPA). Methods and materials: Sixty-two patients underwent either dual-energy CTPA (Group 1: n = 21, 80/Sn140 kVp, 89/38 mAs; Group 2: n = 20, 100/Sn140 kVp, 89/76 mAs) or single-energy CTPA (Group 3: n = 21, 120 kVp, 110 mAs). Blood samples were obtained before and 5 min after CTPA. DSBs were assessed with fluorescence microscopy and Kruskal-Walls tests were used to compare DSBs levels among groups. Volume CT dose index (CTDIvol), dose length product (DLP) and organ radiation dose were compared using ANOVA. Results: There were increased excess DSB foci per lymphocyte 5 min after CTPA examinations in three groups (Group 1: P =.001; Group 2: P =.001; Group 3: P =.006). There were no differences among groups regarding excess DSB foci/cell and percentage of excess DSBs (Group 1, 23%; Group 2, 24%; Group 3, 20%; P =.932). CTDIvol, DLP and organ radiation dose in Group 1 were the lowest among the groups (all P <.001). Conclusion: DSB is increased following dual-source and single-source CTPA, while dual-source dual-energy CT protocols do not increase the estimated radiation dose and also do not result in a higher incidence of DNA DSBs in patients undergoing CTPA.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalEuropean Journal of Radiology
Volume101
DOIs
StatePublished - Apr 2018

Keywords

  • Biological damage
  • CT pulmonary angiography
  • Double-strand breaks
  • Dual-source CT
  • Radiation dose

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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