Comparison of resistance to protein adsorption and stability of thin films derived from α-hepta-(ethylene glycol) methyl ω-undecenyl ether on HSi(111) and HSi(100) surfaces

Chi Ming Yam, Jianhua Gu, Sha Li, Chengzhi Cai

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Oligo(ethylene glycol)-terminated thin films were prepared by photo-induced hydrosilylation of α-hepta-(ethylene glycol) methyl ω-undecenyl ether (EG7) on hydrogen-terminated silicon (111) and (100) surfaces. Their resistance to protein adsorption, and stabilities (from hours to days) under a wide variety of conditions, such as air, water, biological buffer, acid, and base, were investigated using contact-angle goniometry and ellipsometry techniques. Results indicated higher stability of the films chemisorbed on Si(111) than on Si(100). Furthermore, micron-sized patterns were fabricated on the films via AFM anodization lithography. Using atomic force microscopy (AFM) and fluorescence microscopy, we demonstrated that various proteins including fibrinogen, avidin, and bovine serum albumin (BSA) predominately adsorbed onto the patterns, but not the rest of the film surfaces.

Original languageEnglish (US)
Pages (from-to)711-718
Number of pages8
JournalJournal of Colloid And Interface Science
Volume285
Issue number2
DOIs
StatePublished - May 15 2005
Externally publishedYes

Keywords

  • AFM anodization lithography
  • Hydrogen-terminated silicon surfaces
  • Oligo(ethylene glycol)-terminated thin films
  • Photo-induced surface hydrosilylation
  • Protein adsorption
  • Stability

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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