Comparison of radiation dose and image quality: 320-MDCT versus 64-MDCT coronary angiography

Atif Khan, Faisal Khosa, Khurram Nasir, Aya Yassin, Melvin E. Clouse

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


OBJECTIVE. The purpose of this study was to compare radiation dose and image quality of 320- and 64-MDCT angiography using prospective gating. MATERIALS AND METHODS. One hundred seventy-four patients underwent 320-MDCT, and 95 patients underwent 64-MDCT. The scan parameters for 320-MDCT were 120 kVp, 400 mA, and gantry rotation of 350 milliseconds; the parameters for 64-MDCT were 120 kVp, 600 mA, and gantry rotation of 350 milliseconds. Effective dose (ED) was calculated from the dose-length product and a conversion factor (k = 0.014 mSv / mGy x cm). Two observers independently assessed image quality using a 3-point scale, where 3 denotes excellent quality and 1 denotes nondiagnostic quality, using a 16-segment model. Discrepancies were settled by consensus. RESULTS. The ED was significantly lower in patients undergoing 320-MDCT angiography, with a median ED of 4.4 mSv (interquartile range [IQR], 3.4-6.2 mSv), compared with 64-MDCT angiography, with a median ED of 6.2 mSv (IQR, 5.5-6.9 mSv) (p = 0.0001). In patients with a heart rate of 65 beats/min or less (92%), the median radiation dose using 320-MDCT was 4.1 mSv (IQR, 3.2-6.1 mSv), and that for 64-MDCT angiography was 6.2 mSv (IQR, 5.8-6.9 mSv) (p = 0.0001). In patients with heart rate greater than 65 beats/min (8%), the median dose was higher with 320-MDCT (8.7 mSv; IQR, 5.9-14.3 mSv) than with 64-MDCT (5.8 mSv; IQR, 5.3-6.7 mSv) (p = 0.02). Segmental image quality was significantly better for 320-MDCT (excellent or good quality, 96.66%; nondiagnostic quality, 0.1%) than for 64-MDCT angiography (excellent or good quality, 86%; nondiagnostic quality, 3.33%) (all p < 0.0001). CONCLUSION. Image quality was good for both 320- and 64-MDCT angiography. Overall radiation dose was significantly lower in 320-MDCT angiography when the heart rate was 65 beats/min or less. Every effort should be made to control heart rate to minimize radiation dose.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalAmerican Journal of Roentgenology
Issue number1
StatePublished - Jul 2011


  • 320-MDCT
  • 64-MDCT
  • Coronary artery disease
  • Image quality
  • Radiation dose

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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