Comparison of outcomes between metaplastic and triple-negative breast cancer patients

Research output: Contribution to journalArticle

Praveen Polamraju, Waqar M. Haque, Kevin Cao, Vivek Verma, Mary Schwartz, V. Suzanne Klimberg, Sandra Hatch, Polly A. Niravath, Edward Brian Butler, Bin S. Teh

Purpose: Metaplastic breast cancer (MBC) is a rare, aggressive variant of breast cancer that has been associated with poor clinical outcomes, as has triple-negative breast (TNBC) cancer. Limited studies compare the clinical characteristics and prognosis of MBC to TNBC. This study uses a large, contemporary US cancer database to compare clinical characteristics and survival outcomes for patients with MBC to those with TNBC. Methods: The National Cancer Database was queried for women with cT1-4N1-3M0 MBC or TNBC diagnosed between 2004 and 2013 and treated with definitive surgery. Chi-squared analysis was performed to determine differences between the cohorts. Kaplan-Meier curves compared overall survival (OS), and Cox regression determined patient factors associated with OS. Results: Altogether, 55,847 patients met the inclusion criteria; 50,705 (90.8%) had TNBC and 5,142 (9.2%) had MBC. Most patients had no comorbid conditions (82%), N0 disease (71%), poorly differentiated histology (77%), received chemotherapy (87%), and received radiation therapy (60%). Amongst all patients, patients with TNBC disease were observed to have greater OS than those with MBC (5-year OS 72.0% vs 55.8%, p < 0.001). The greater observed OS for patients with TNBC persisted when controlling for stage and when comparing propensity score matched cohorts. On Cox regression, lower age, T1 status, N0 status, chemotherapy, TNBC disease, and radiation therapy (RT) were associated with improved OS. Conclusions: MBC had an association with poorer OS compared to TNBC, while RT and chemotherapy receipt were associated with improved OS for patients regardless of stage. Further studies are needed to corroborate the conclusions herein.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalBreast
Volume49
DOIs
StatePublished - Feb 1 2020

PMID: 31675684

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Comparison of outcomes between metaplastic and triple-negative breast cancer patients. / Polamraju, Praveen; Haque, Waqar M.; Cao, Kevin; Verma, Vivek; Schwartz, Mary; Klimberg, V. Suzanne; Hatch, Sandra; Niravath, Polly A.; Butler, Edward Brian; Teh, Bin S.

In: Breast, Vol. 49, 01.02.2020, p. 8-16.

Research output: Contribution to journalArticle

Harvard

Polamraju, P, Haque, WM, Cao, K, Verma, V, Schwartz, M, Klimberg, VS, Hatch, S, Niravath, PA, Butler, EB & Teh, BS 2020, 'Comparison of outcomes between metaplastic and triple-negative breast cancer patients' Breast, vol. 49, pp. 8-16. https://doi.org/10.1016/j.breast.2019.10.003

APA

Polamraju, P., Haque, W. M., Cao, K., Verma, V., Schwartz, M., Klimberg, V. S., ... Teh, B. S. (2020). Comparison of outcomes between metaplastic and triple-negative breast cancer patients. Breast, 49, 8-16. https://doi.org/10.1016/j.breast.2019.10.003

Vancouver

Polamraju P, Haque WM, Cao K, Verma V, Schwartz M, Klimberg VS et al. Comparison of outcomes between metaplastic and triple-negative breast cancer patients. Breast. 2020 Feb 1;49:8-16. https://doi.org/10.1016/j.breast.2019.10.003

Author

Polamraju, Praveen ; Haque, Waqar M. ; Cao, Kevin ; Verma, Vivek ; Schwartz, Mary ; Klimberg, V. Suzanne ; Hatch, Sandra ; Niravath, Polly A. ; Butler, Edward Brian ; Teh, Bin S. / Comparison of outcomes between metaplastic and triple-negative breast cancer patients. In: Breast. 2020 ; Vol. 49. pp. 8-16.

BibTeX

@article{ab207daa58d04cbf879f320856342176,
title = "Comparison of outcomes between metaplastic and triple-negative breast cancer patients",
abstract = "Purpose: Metaplastic breast cancer (MBC) is a rare, aggressive variant of breast cancer that has been associated with poor clinical outcomes, as has triple-negative breast (TNBC) cancer. Limited studies compare the clinical characteristics and prognosis of MBC to TNBC. This study uses a large, contemporary US cancer database to compare clinical characteristics and survival outcomes for patients with MBC to those with TNBC. Methods: The National Cancer Database was queried for women with cT1-4N1-3M0 MBC or TNBC diagnosed between 2004 and 2013 and treated with definitive surgery. Chi-squared analysis was performed to determine differences between the cohorts. Kaplan-Meier curves compared overall survival (OS), and Cox regression determined patient factors associated with OS. Results: Altogether, 55,847 patients met the inclusion criteria; 50,705 (90.8{\%}) had TNBC and 5,142 (9.2{\%}) had MBC. Most patients had no comorbid conditions (82{\%}), N0 disease (71{\%}), poorly differentiated histology (77{\%}), received chemotherapy (87{\%}), and received radiation therapy (60{\%}). Amongst all patients, patients with TNBC disease were observed to have greater OS than those with MBC (5-year OS 72.0{\%} vs 55.8{\%}, p < 0.001). The greater observed OS for patients with TNBC persisted when controlling for stage and when comparing propensity score matched cohorts. On Cox regression, lower age, T1 status, N0 status, chemotherapy, TNBC disease, and radiation therapy (RT) were associated with improved OS. Conclusions: MBC had an association with poorer OS compared to TNBC, while RT and chemotherapy receipt were associated with improved OS for patients regardless of stage. Further studies are needed to corroborate the conclusions herein.",
keywords = "Breast cancer, Chemotherapy, Metaplastic, Radiation therapy, Triple-negative",
author = "Praveen Polamraju and Haque, {Waqar M.} and Kevin Cao and Vivek Verma and Mary Schwartz and Klimberg, {V. Suzanne} and Sandra Hatch and Niravath, {Polly A.} and Butler, {Edward Brian} and Teh, {Bin S.}",
year = "2020",
month = "2",
day = "1",
doi = "10.1016/j.breast.2019.10.003",
language = "English (US)",
volume = "49",
pages = "8--16",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - Comparison of outcomes between metaplastic and triple-negative breast cancer patients

AU - Polamraju, Praveen

AU - Haque, Waqar M.

AU - Cao, Kevin

AU - Verma, Vivek

AU - Schwartz, Mary

AU - Klimberg, V. Suzanne

AU - Hatch, Sandra

AU - Niravath, Polly A.

AU - Butler, Edward Brian

AU - Teh, Bin S.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Purpose: Metaplastic breast cancer (MBC) is a rare, aggressive variant of breast cancer that has been associated with poor clinical outcomes, as has triple-negative breast (TNBC) cancer. Limited studies compare the clinical characteristics and prognosis of MBC to TNBC. This study uses a large, contemporary US cancer database to compare clinical characteristics and survival outcomes for patients with MBC to those with TNBC. Methods: The National Cancer Database was queried for women with cT1-4N1-3M0 MBC or TNBC diagnosed between 2004 and 2013 and treated with definitive surgery. Chi-squared analysis was performed to determine differences between the cohorts. Kaplan-Meier curves compared overall survival (OS), and Cox regression determined patient factors associated with OS. Results: Altogether, 55,847 patients met the inclusion criteria; 50,705 (90.8%) had TNBC and 5,142 (9.2%) had MBC. Most patients had no comorbid conditions (82%), N0 disease (71%), poorly differentiated histology (77%), received chemotherapy (87%), and received radiation therapy (60%). Amongst all patients, patients with TNBC disease were observed to have greater OS than those with MBC (5-year OS 72.0% vs 55.8%, p < 0.001). The greater observed OS for patients with TNBC persisted when controlling for stage and when comparing propensity score matched cohorts. On Cox regression, lower age, T1 status, N0 status, chemotherapy, TNBC disease, and radiation therapy (RT) were associated with improved OS. Conclusions: MBC had an association with poorer OS compared to TNBC, while RT and chemotherapy receipt were associated with improved OS for patients regardless of stage. Further studies are needed to corroborate the conclusions herein.

AB - Purpose: Metaplastic breast cancer (MBC) is a rare, aggressive variant of breast cancer that has been associated with poor clinical outcomes, as has triple-negative breast (TNBC) cancer. Limited studies compare the clinical characteristics and prognosis of MBC to TNBC. This study uses a large, contemporary US cancer database to compare clinical characteristics and survival outcomes for patients with MBC to those with TNBC. Methods: The National Cancer Database was queried for women with cT1-4N1-3M0 MBC or TNBC diagnosed between 2004 and 2013 and treated with definitive surgery. Chi-squared analysis was performed to determine differences between the cohorts. Kaplan-Meier curves compared overall survival (OS), and Cox regression determined patient factors associated with OS. Results: Altogether, 55,847 patients met the inclusion criteria; 50,705 (90.8%) had TNBC and 5,142 (9.2%) had MBC. Most patients had no comorbid conditions (82%), N0 disease (71%), poorly differentiated histology (77%), received chemotherapy (87%), and received radiation therapy (60%). Amongst all patients, patients with TNBC disease were observed to have greater OS than those with MBC (5-year OS 72.0% vs 55.8%, p < 0.001). The greater observed OS for patients with TNBC persisted when controlling for stage and when comparing propensity score matched cohorts. On Cox regression, lower age, T1 status, N0 status, chemotherapy, TNBC disease, and radiation therapy (RT) were associated with improved OS. Conclusions: MBC had an association with poorer OS compared to TNBC, while RT and chemotherapy receipt were associated with improved OS for patients regardless of stage. Further studies are needed to corroborate the conclusions herein.

KW - Breast cancer

KW - Chemotherapy

KW - Metaplastic

KW - Radiation therapy

KW - Triple-negative

UR - http://www.scopus.com/inward/record.url?scp=85074033261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074033261&partnerID=8YFLogxK

U2 - 10.1016/j.breast.2019.10.003

DO - 10.1016/j.breast.2019.10.003

M3 - Article

VL - 49

SP - 8

EP - 16

JO - Breast

T2 - Breast

JF - Breast

SN - 0960-9776

ER -

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