Comparison of methotrexate and cisplatin for patients with advanced squamous cell carcinoma of the head and neck region: A southwest oncology group study

W. E. Grose, Daniel E. Lehane, D. O. Dixon, W. S. Fletcher, W. J. Stuckey

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

One hundred eligible patients with inoperable, locally advanced or metastatic squamous cell carcinoma of the head and neck region following prior therapy were randomized to receive im methotrexate (50 patients) or iv cisplatin (50 patients). Methotrexate produced a complete plus partial response rate of 16.0% and cisplatin produced a partial response rate of 8.0%, with median durations of response of 18 and 8 weeks, respectively. The corresponding median survivaltimes were 20 and 18 weeks. Methotrexate responders survived 60 weeks, versus 17 weeks for nonresponders. The corresponding survival times for cisplatin-treated patients were 38 and 18 weeks. Good pretreatment performance status had a significantly positive effect on survival (P = 0.04), but prior therapy did not. Toxicity secondary to either agent occurred with the expected frequency. The two agents examined showed comparable antitumor activity in patients with squamous cell carcinoma of the head and neck who had not previously received chemotherapy.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalCancer Treatment Reports
Volume69
Issue number6
StatePublished - Oct 2 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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