TY - JOUR
T1 - Comparison of intra-arterial cis-diamminedichloroplatinum II with high-dose methotrexate and citrovorum factor rescue in the treatment of primary osteosarcoma
AU - Jaffe, N.
AU - Robertson, R.
AU - Ayala, Alberto
AU - Wallace, S.
AU - Chuang, V.
AU - Anzai, T.
AU - Cangir, A.
AU - Wang, Y. M.
AU - Chen, T.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - A randomized two-arm study was undertaken to determine relative tumoricidal effects of intra-arterial cis-diamminedichloroplatinum II (I/A-CDP) and high-dose methotrexate with citrovorum factor rescue (MTX-CF) in the treatment of the primary tumor in patients with osteosarcoma. Responses were evaluated by clinical, radiographic, angiographic, and pathologic parameters. Fifteen patients were randomized to receive MTX-CF and 15 to I/A-CDP. In the MTX-CF arm there were four responses (three complete responses, one partial response) whereas in the I/A CDP arm there were nine responses (seven complete responses, two partial responses). Two patients who failed MTX-CF and requested alternative treatment with I/A-CDP also responded. The total I/A-CDP response was 11/17.
AB - A randomized two-arm study was undertaken to determine relative tumoricidal effects of intra-arterial cis-diamminedichloroplatinum II (I/A-CDP) and high-dose methotrexate with citrovorum factor rescue (MTX-CF) in the treatment of the primary tumor in patients with osteosarcoma. Responses were evaluated by clinical, radiographic, angiographic, and pathologic parameters. Fifteen patients were randomized to receive MTX-CF and 15 to I/A-CDP. In the MTX-CF arm there were four responses (three complete responses, one partial response) whereas in the I/A CDP arm there were nine responses (seven complete responses, two partial responses). Two patients who failed MTX-CF and requested alternative treatment with I/A-CDP also responded. The total I/A-CDP response was 11/17.
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U2 - 10.1200/JCO.1985.3.8.1101
DO - 10.1200/JCO.1985.3.8.1101
M3 - Article
C2 - 3874932
AN - SCOPUS:0021830031
SN - 0732-183X
VL - 3
SP - 1101
EP - 1104
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 8
ER -